Glutathione S-transferase polymorphisms (GSTM1/GSTT1) outcomes in clinical profile and treatment responsiveness among Tunisian cohort of Parkinson's disease.

Autor:	Guedi AB; Neurology Department LR18SP03, Razi University Hospital, 1 rue des Orangers Manouba, Tunis, PC: 2010, Tunisia.; Clinical Investigation Center (CIC) 'Neurosciences and Mental Health', Razi University Hospital, 1 rue des Orangers Manouba, Tunis, 2010, Tunisia., Ikram S; Neurology Department LR18SP03, Razi University Hospital, 1 rue des Orangers Manouba, Tunis, PC: 2010, Tunisia.; Clinical Investigation Center (CIC) 'Neurosciences and Mental Health', Razi University Hospital, 1 rue des Orangers Manouba, Tunis, 2010, Tunisia., Youssef A; Neurology Department LR18SP03, Razi University Hospital, 1 rue des Orangers Manouba, Tunis, PC: 2010, Tunisia.; Faculty of Medicine of Tunis, University of Tunis El Manar, 15, Rue Djebel Akhdhar, La Rabta, Tunis, 1007, Tunisia.; Clinical Investigation Center (CIC) 'Neurosciences and Mental Health', Razi University Hospital, 1 rue des Orangers Manouba, Tunis, 2010, Tunisia., Alya G; Neurology Department LR18SP03, Razi University Hospital, 1 rue des Orangers Manouba, Tunis, PC: 2010, Tunisia.; Faculty of Medicine of Tunis, University of Tunis El Manar, 15, Rue Djebel Akhdhar, La Rabta, Tunis, 1007, Tunisia.; Clinical Investigation Center (CIC) 'Neurosciences and Mental Health', Razi University Hospital, 1 rue des Orangers Manouba, Tunis, 2010, Tunisia., Amira S; Neurology Department LR18SP03, Razi University Hospital, 1 rue des Orangers Manouba, Tunis, PC: 2010, Tunisia.; Faculty of Medicine of Tunis, University of Tunis El Manar, 15, Rue Djebel Akhdhar, La Rabta, Tunis, 1007, Tunisia.; Clinical Investigation Center (CIC) 'Neurosciences and Mental Health', Razi University Hospital, 1 rue des Orangers Manouba, Tunis, 2010, Tunisia., Saloua M; Neurology Department LR18SP03, Razi University Hospital, 1 rue des Orangers Manouba, Tunis, PC: 2010, Tunisia.; Faculty of Medicine of Tunis, University of Tunis El Manar, 15, Rue Djebel Akhdhar, La Rabta, Tunis, 1007, Tunisia.; Clinical Investigation Center (CIC) 'Neurosciences and Mental Health', Razi University Hospital, 1 rue des Orangers Manouba, Tunis, 2010, Tunisia., Amina N; Neurology Department LR18SP03, Razi University Hospital, 1 rue des Orangers Manouba, Tunis, PC: 2010, Tunisia.; Faculty of Medicine of Tunis, University of Tunis El Manar, 15, Rue Djebel Akhdhar, La Rabta, Tunis, 1007, Tunisia.; Clinical Investigation Center (CIC) 'Neurosciences and Mental Health', Razi University Hospital, 1 rue des Orangers Manouba, Tunis, 2010, Tunisia., Mouna BD; Neurology Department LR18SP03, Razi University Hospital, 1 rue des Orangers Manouba, Tunis, PC: 2010, Tunisia.; Faculty of Medicine of Tunis, University of Tunis El Manar, 15, Rue Djebel Akhdhar, La Rabta, Tunis, 1007, Tunisia.; Clinical Investigation Center (CIC) 'Neurosciences and Mental Health', Razi University Hospital, 1 rue des Orangers Manouba, Tunis, 2010, Tunisia., Imen K; Neurology Department LR18SP03, Razi University Hospital, 1 rue des Orangers Manouba, Tunis, PC: 2010, Tunisia.; Faculty of Medicine of Tunis, University of Tunis El Manar, 15, Rue Djebel Akhdhar, La Rabta, Tunis, 1007, Tunisia.; Clinical Investigation Center (CIC) 'Neurosciences and Mental Health', Razi University Hospital, 1 rue des Orangers Manouba, Tunis, 2010, Tunisia., Amina GB; Neurology Department LR18SP03, Razi University Hospital, 1 rue des Orangers Manouba, Tunis, PC: 2010, Tunisia.; Faculty of Medicine of Tunis, University of Tunis El Manar, 15, Rue Djebel Akhdhar, La Rabta, Tunis, 1007, Tunisia.; Clinical Investigation Center (CIC) 'Neurosciences and Mental Health', Razi University Hospital, 1 rue des Orangers Manouba, Tunis, 2010, Tunisia., Riadh G; Neurology Department LR18SP03, Razi University Hospital, 1 rue des Orangers Manouba, Tunis, PC: 2010, Tunisia. riadh.gouider@gnet.tn.; Faculty of Medicine of Tunis, University of Tunis El Manar, 15, Rue Djebel Akhdhar, La Rabta, Tunis, 1007, Tunisia. riadh.gouider@gnet.tn.; Clinical Investigation Center (CIC) 'Neurosciences and Mental Health', Razi University Hospital, 1 rue des Orangers Manouba, Tunis, 2010, Tunisia. riadh.gouider@gnet.tn.; Research Laboratory 'Neurodegenerative Diseases and Psychiatric Disorders', LR18SP03, Tunis, poste 522, Tunisia. riadh.gouider@gnet.tn.
Jazyk:	angličtina
Zdroj:	Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2024 Aug 09. Date of Electronic Publication: 2024 Aug 09.
DOI:	10.1007/s00702-024-02815-w
Abstrakt:	Glutathione S-transferases are involved in the oxidative stress which contributes to the pathogenesis of Parkinson's disease (PD). our aim was to investigate the influence of GSTM1 and GSTT1 polymorphisms on the clinical features and treatments outcomes among PD Tunisian patients. We included 300-PD patients followed in neurology department at Razi-University-hospital. GSTM1 and GSTT1 were screened using PCR methods. Correlation between the clinical phenotype and the genotypes was then assessed after adequate parameters adjustment. Individuals carrying inactive GSTT1/GSTM1 were estimated to have 2.5-fold higher risk of developing PD, p = 0.035. The demographic and clinical baseline analysis of GSTM1 polymorphism revealed significant association between the inactive gene and development of tremor as first symptoms (p = 0.046), further, it was correlated to asymmetric start (p = 0.044). The evaluation of the impact of GSTM1/GSTT1 activity among PD at last follow-up revealed the significant variability of motor impairment among cases carrier of the active genes (p = 0.048). As patients with inactive GSTM1/GSTT1 had higher UPDRS-III score. Additionally, higher frequency of cases with good treatment responsiveness was reported among PD with active GSTM1/GSTT1 (p = 0.038).No motor complications were observed among PD by considering the GSTs genotypes (p > 0.05). Finally, we noted significant impairment of memory among cases with inactivate GSTs (p = 0.04), attention deficit (p = 0.013) and impaired judgement (p = 0.0031). This study represents one of the most comprehensive and extensive investigation to date regarding the influence of GSTT1/GSTM1 genotype among PD patients.We speculate that the impact of GSTT1/GSTM1 on PD progression may occur through a cumulative effect, potentially not manifesting during the initial PD stages. Further studies are necessary to validate our conclusions. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.)
Databáze:	MEDLINE
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