Late-onset vitamin K deficiency presenting as haemorrhagic shock and severe multi-system organ failure.

Autor:	Azar JM; Janet Weis Children's Hospital, Danville, Pennsylvania, USA justin.azar@gmail.com.; Pediatrics, Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania, USA., Lambert R; Janet Weis Children's Hospital, Danville, Pennsylvania, USA.; Pediatrics, Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania, USA., Maffei FA; Janet Weis Children's Hospital, Danville, Pennsylvania, USA.; Pediatrics, Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania, USA., Thomas TA; Janet Weis Children's Hospital, Danville, Pennsylvania, USA.; Pediatrics, Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania, USA.
Jazyk:	angličtina
Zdroj:	BMJ case reports [BMJ Case Rep] 2024 Aug 08; Vol. 17 (8). Date of Electronic Publication: 2024 Aug 08.
DOI:	10.1136/bcr-2024-261126
Abstrakt:	Vitamin K is an essential dietary cofactor required for the synthesis of active forms of vitamin K-dependent procoagulant proteins. Vitamin K deficiency, particularly late-onset deficiency occurring between 1 week and 6 months of age, can cause a life-threatening bleeding disorder. An exclusively breastfed, full-term, 6-week-old infant male presented with severe haemorrhagic shock and multi-system organ failure related to caregiver refusal of intramuscular vitamin K after birth. Coagulation studies were normalised within 8 hours of intramuscular vitamin K administration. An increasing number of caregivers are refusing intramuscular vitamin K which has led to a rise in the incidence of vitamin K deficiency bleeding. Health policy organisations around the world emphasise the benefits of intramuscular vitamin K and risks of refusal, particularly in exclusively breastfed infants who are at higher risk due to low vitamin K levels in breast milk. This case highlights the multi-system severity of this life-threatening yet preventable disorder. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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