Trends in heart transplant outcomes for patients over the age of 70 years in the United States: An analysis of the scientific registry of transplant recipients database.

Autor:	Henricksen EJ; Department of Transplant - Stanford Medicine, Stanford, California. Electronic address: ehenricksen@stanfordhealthcare.org., Wayda B; Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California., Teuteberg JJ; Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California., Luikart H; Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California., Njoroge J; Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California., Guenthart BA; Cardiothoracic Surgery, Department of Surgery, Stanford University, Stanford, California., Khush KK; Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California.
Jazyk:	angličtina
Zdroj:	The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 2024 Aug 08. Date of Electronic Publication: 2024 Aug 08.
DOI:	10.1016/j.healun.2024.08.001
Abstrakt:	Background: Patients of advanced age are often considered to be poor candidates for heart transplant (HT). As the U.S. population continues to age, it is important for clinicians to understand how best to select patients for advanced therapies. Methods: This was a retrospective analysis of the U.S. Scientific Registry of Transplant Recipients data from 2006 to August 2022 in adult recipients. Patients were excluded if they were multiorgan transplant, re-do transplants, or less than 1 year post transplant. Results: Recipients ≥70 had a 1-year survival of 87.5%, compared to 91.1% for <60%, and 88.4% for 60-69 years (p < 0.001). Survival improved numerically, but not significantly, as transplant eras progressed for those ≥70 years. Survival by Kaplan-Meier analysis was greatest at 5 years for <60 years (80.6%), compared to 60-69 years (78.2%) and ≥70 years (77.1%). When comparing 60-69 years to ≥70 years by this same metric, there was significant difference (p = 0.12). One year survival for those ≥70 years has improved from 2000-2009 (80.7%) to 88.5% since October 2018 (p < 0.001). As recipients increased in age, they were more likely to be male, and less likely to be Black or Hispanic/Latino (p < 0.001). Conclusion: Overall, HT outcomes are excellent for carefully selected patients ≥70 years, and transplanting patients in this age cohort can be considered. (Copyright © 2024 International Society for the Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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