Unraveling the ncRNA landscape that governs colorectal cancer: A roadmap to personalized therapeutics.

Autor: Hamdy NM; Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abbasia Cairo, 11566, Egypt. Electronic address: nadia_hamdy@pharma.asu.edu.eg., Zaki MB; Department of Biochemistry, Faculty of Pharmacy, University of Sadat City, Menoufia, 32897, Egypt., Rizk NI; Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Abdelmaksoud NM; Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Abd-Elmawla MA; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Kasr Al Ainy, Cairo, 11562, Egypt., Ismail RA; Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Abulsoud AI; Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al Azhar University, Nasr City, Cairo, 11231, Egypt.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2024 Oct 01; Vol. 354, pp. 122946. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1016/j.lfs.2024.122946
Abstrakt: Colorectal cancer (CRC) being one of the most common malignancies, has a significant death rate, especially when detected at an advanced stage. In most cases, the fundamental aetiology of CRC remains unclear despite the identification of several environmental and intrinsic risk factors. Numerous investigations, particularly in the last ten years, have indicated the involvement of epigenetic variables in this type of cancer. The development, progression, and metastasis of CRC are influenced by long non-coding RNAs (lncRNAs), which are significant players in the epigenetic pathways. LncRNAs are implicated in diverse pathological processes in CRC, such as liver metastasis, epithelial to mesenchymal transition (EMT), inflammation, and chemo-/radioresistance. It has recently been determined that CRC cells and tissues exhibit dysregulation of tens of oncogenic and tumor suppressor lncRNAs. Serum samples from CRC patients exhibit dysregulated expressions of several of these transcripts, offering a non-invasive method of detecting this kind of cancer. In this review, we outlined the typical paradigms of the deregulated lncRNA which exert significant role in the underlying molecular mechanisms of CRC initiation and progression. We comprehensively discuss the role of lncRNAs as innovative targets for CRC prognosis and treatment.
Competing Interests: Declaration of competing interest The authors declare no competing interests.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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