Refining Treatment Planning in STereotactic Arrhythmia Radioablation: Benchmark Results and Consensus Statement From the STOPSTORM.eu Consortium.
| Autor: | Trojani V; Department of Medical Physics, AUSL-IRCCS Reggio Emilia, Reggio Emilia, Italy., Grehn M; Department of Radiation Oncology, University Medical Center of Schleswig-Holstein, Kiel, Germany., Botti A; Department of Medical Physics, AUSL-IRCCS Reggio Emilia, Reggio Emilia, Italy., Balgobind B; Department of Radiation Oncology, Amsterdam UMC, Radiation Oncology, Amsterdam, The Netherlands., Savini A; Department of Medical Physics, G. Mazzini Hospital, Teramo, Italy., Boda-Heggemann J; Department of Radiation Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Miszczyk M; IIIrd Radiotherapy and Chemotherapy Department, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice, Poland; Collegium Medicum - Faculty of Medicine, WSB University, Dąbrowa Górnicza, Poland., Elicin O; Department of Radiation Oncology and Division of Medical Radiation Physics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Krug D; Department of Radiation Oncology, University Medical Center of Schleswig-Holstein, Kiel, Germany., Andratschke N; Department of Radiation Oncology, University Hospital of Zurich, Zurich, Switzerland., Schmidhalter D; Department of Radiation Oncology and Division of Medical Radiation Physics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., van Elmpt W; Department of Radiation Oncology (Maastro), GROW School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands., Bogowicz M; Department of Radiation Oncology (Maastro), GROW School for Oncology and Reproduction, Maastricht University Medical Center+, Maastricht, The Netherlands., de Areba Iglesias J; Department of Medical Physics, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Dolla L; Radiotherapy Planning Department, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice, Poland., Ehrbar S; Department of Radiation Oncology, University Hospital of Zurich, Zurich, Switzerland., Fernandez-Velilla E; Department of Radiotherapy, Hospital del Mar, Universitat Pompeu Fabra, Barcelona, Spain., Fleckenstein J; Department of Radiation Oncology, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Granero D; Department of Radiation Oncology, Hospital General Valencia, Valencia, Spain., Henzen D; Department of Radiation Oncology and Division of Medical Radiation Physics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Hurkmans C; Department of Radiation Oncology, Catharina Hospital, Eindhoven, The Netherlands; Department of Electrical Engineering and Department of Applied Physics, Technical University Eindhoven, The Netherlands., Kluge A; Department for Radiation Oncology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Knybel L; Department of Oncology, University Hospital and Faculty of Medicine, Ostrava, Czech Republic., Loopeker S; Department of Radiation Oncology, Amsterdam UMC, Radiation Oncology, Amsterdam, The Netherlands., Mirandola A; Radiation Oncology Clinical Department, National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy., Richetto V; Medical Physics Unit, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy., Sicignano G; Department of Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy., Vallet V; Department of Radiophysics, Lausanne University Hospital, Lausanne, Switzerland., van Asselen B; Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands., Worm E; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Pruvot E; Heart and Vessel Department, Service of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Verhoeff J JC; Department of Radiation Oncology, Amsterdam UMC, Radiation Oncology, Amsterdam, The Netherlands; Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands., Fast M F; Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands., Iori M; Department of Medical Physics, AUSL-IRCCS Reggio Emilia, Reggio Emilia, Italy., Blanck O; Department of Radiation Oncology, University Medical Center of Schleswig-Holstein, Kiel, Germany. Electronic address: oliver.blanck@uksh.de. |
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| Jazyk: | angličtina |
| Zdroj: | International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2024 Aug 08. Date of Electronic Publication: 2024 Aug 08. |
| DOI: | 10.1016/j.ijrobp.2024.07.2331 |
| Abstrakt: | Purpose: STereotactic Arrhythmia Radioablation (STAR) showed promising results in patients with refractory ventricular tachycardia. However, clinical data are scarce and heterogeneous. The STOPSTORM.eu consortium was established to investigate and harmonize STAR in Europe. The primary goal of this benchmark study was to investigate current treatment planning practice within the STOPSTORM project as a baseline for future harmonization. Methods and Materials: Planning target volumes (PTVs) overlapping extracardiac organs-at-risk and/or cardiac substructures were generated for 3 STAR cases. Participating centers were asked to create single-fraction treatment plans with 25 Gy dose prescriptions based on in-house clinical practice. All treatment plans were reviewed by an expert panel and quantitative crowd knowledge-based analysis was performed with independent software using descriptive statistics for International Commission on Radiation Units and Measurements report 91 relevant parameters and crowd dose-volume histograms. Thereafter, treatment planning consensus statements were established using a dual-stage voting process. Results: Twenty centers submitted 67 treatment plans for this study. In most plans (75%) intensity modulated arc therapy with 6 MV flattening filter free beams was used. Dose prescription was mainly based on PTV D Conclusions: This STOPSTORM multicenter treatment planning benchmark study not only showed strong agreement on several aspects of STAR treatment planning, but also revealed disagreement on others. To standardize and harmonize STAR in the future, consensus statements were established; however, clinical data are urgently needed for actionable guidelines for treatment planning. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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