High sperm deoxyribonucleic acid fragmentation index is associated with an increased risk of preeclampsia following assisted reproduction treatment.

Autor:	Stenqvist A; Molecular Reproductive Medicine, Department of Translational Medicine, Lund University, Malmö, Sweden; Reproductive Medicine Centre, Skåne University Hospital, Malmö, Sweden; Department of Obstetrics and Gynaecology, Skåne University Hospital, Malmö/Lund, Sweden. Electronic address: ameliestenqvist@med.lu.se., Bungum M; Reproductive Medicine Centre, Skåne University Hospital, Malmö, Sweden., Pinborg AB; Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Bogstad J; Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Englund AL; Fertility Clinic, Zealand University Hospital, Koege, Denmark., Grøndahl ML; Fertility Clinic, Copenhagen University Hospital, Herlev Hospital, Herlev, Denmark., Zedeler A; Department of Obstetrics and Gynaecology, The Fertility Clinic, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Hansson SR; Department of Obstetrics and Gynaecology, Skåne University Hospital, Malmö/Lund, Sweden; Obstetrics and Gynaecology, Department of Clinical Sciences Lund, Lund University, Sweden., Giwercman A; Molecular Reproductive Medicine, Department of Translational Medicine, Lund University, Malmö, Sweden; Reproductive Medicine Centre, Skåne University Hospital, Malmö, Sweden.
Jazyk:	angličtina
Zdroj:	Fertility and sterility [Fertil Steril] 2024 Aug 08. Date of Electronic Publication: 2024 Aug 08.
DOI:	10.1016/j.fertnstert.2024.08.316
Abstrakt:	Objective: To study the association between sperm deoxyribonucleic acid fragmentation index (DFI) and the odds of preeclampsia and other adverse perinatal outcomes after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment. Design: A prospective cohort study including infertile couples undergoing conventional IVF or ICSI treatment and their children. Data regarding preeclampsia and perinatal outcomes were derived from the Swedish National Birth Register. Setting: University-affiliated fertility clinic. Patient(s): A total of 1,594 infertile couples undergoing IVF or ICSI treatment and their 1,660 children conceived by assisted reproduction. Intervention(s): Sperm DFI measured by Sperm Chromatin Structure Assay. Main Outcome Measure(s): The primary outcome was preeclampsia. The secondary outcomes were preterm birth (PTB), low birth weight, low Apgar score, and small for gestational age. Result(s): With a DFI level of <20% as a reference, the odds ratio (OR) of preeclampsia statistically significantly increased in the group with a DFI level of ≥20% when IVF was used as the fertilization method (OR, 2.2; 95% confidence interval, 1.1-4.4). Already at the DFI levels of ≥10%, in IVF pregnancies, the OR of preeclampsia increased in a dose-response manner, from a prevalence of 3.1% in the reference group to >10% among those with a DFI level of ≥30%. The DFI was not associated with the OR of preeclampsia in the ICSI group. In the entire cohort, a DFI level of ≥20% was associated with an increased OR of PTB (OR, 1.4; 95% confidence interval, 1.0-2.0). Conclusion(s): High DFI level was associated with increased odds of PTB and, in IVF pregnancies, also increased odds of preeclampsia. Competing Interests: Declaration of Interests A.S. has nothing to disclose. M.B. has nothing to disclose. A.B.P. has received grants (payments to institution) from Gedeon Richter, Ferring Pharmaceuticals, and Merck A/S; consulting fees from PregLem, Novo Nordisk, Ferring Pharmaceuticals, Gedeon Richter, Cryos, and Merck A/S; and payment for lectures/presentations from Gedeon Richter, Ferring Pharmaceuticals, Merck A/S, Theramex, and Organon. J.B. has nothing to disclose. A.L.E. has nothing to disclose. M.L.G. has received payments for lectures/presentations from Merck A/S. A.Z. has received grants and payments for lectures/presentations by Gedeon Richter. S.R.H. has nothing to disclose. A.G. has nothing to disclose. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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