Informing an investment case for Japanese encephalitis vaccine introduction in Bangladesh.

Autor: Duque MP; Pathogen Dynamics Group, Department of Genetics, University of Cambridge, Cambridge, UK., Naser AM; International Centre for Diarrheal Diseases Research, Bangladesh (icddr,b), Dhaka, Bangladesh.; Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA., Dos Santos GR; Pathogen Dynamics Group, Department of Genetics, University of Cambridge, Cambridge, UK., O'Driscoll M; Pathogen Dynamics Group, Department of Genetics, University of Cambridge, Cambridge, UK., Paul KK; International Centre for Diarrheal Diseases Research, Bangladesh (icddr,b), Dhaka, Bangladesh.; School of Population Health, University of New South Wales, Sydney, NSW, Australia., Rahman M; Institute for Epidemiology, Disease Control and Research (IEDCR), Dhaka, Bangladesh., Alam MS; International Centre for Diarrheal Diseases Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Al-Amin HM; International Centre for Diarrheal Diseases Research, Bangladesh (icddr,b), Dhaka, Bangladesh.; School of the Environment, The University of Queensland, Brisbane, QLD, Australia., Rahman MZ; International Centre for Diarrheal Diseases Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Hossain ME; International Centre for Diarrheal Diseases Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Paul RC; Centre for Big Data Research in Health, University of New South Wales, Sydney, NSW, Australia., Luby SP; Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA., Cauchemez S; Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Université Paris Cité, UMR 2000 CNRS, Paris, France., Vanhomwegen J; Emerging Diseases Unit, Institut Pasteur, Paris, France., Gurley ES; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Salje H; Pathogen Dynamics Group, Department of Genetics, University of Cambridge, Cambridge, UK.
Jazyk: angličtina
Zdroj: Science advances [Sci Adv] 2024 Aug 09; Vol. 10 (32), pp. eadp1657. Date of Electronic Publication: 2024 Aug 09.
DOI: 10.1126/sciadv.adp1657
Abstrakt: Japanese encephalitis virus (JEV) is a major threat to human health. Bangladesh is considering introducing a JEV vaccine; however, the investment case is hampered by a limited understanding of key aspects of JEV ecology. We conducted a seroprevalence study in a high-incidence region using an assay that limits cross-reactivity with dengue virus. We also trapped mosquitoes and collected information about potential host species. We used mathematical models to recover risk factors for infection and underlying probabilities of severe disease and death. We observed 19.0% [95% confidence interval (CI):17.1 to 21.1] of JEV antibodies. On average, 0.7% (95% CI: 0.2 to 2.0) of the susceptible population gets infected yearly, with pig proximity being the main human infection risk factor. Our traps captured 10 different mosquito species that have been linked with JEV transmission. We estimated that 1 in 1000 infections results in severe disease, 1 in 10,000 results in death, and 76% of severe cases are missed by surveillance.
Databáze: MEDLINE