The aperiodic exponent of neural activity varies with vigilance state in mice and men.

Autor: Østergaard FG; University of Groningen, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands., Penninx BWJH; Department of Psychiatry and Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands., Das N; Biotrial, Rennes, France., Arango C; Child and Adolescent Department, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Madrid, Spain.; CIBERSAM, IiSGM, School of Medicine, Universidad Complutense, Madrid, Spain., van der Wee N; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.; Leiden Institute for Brain and Cognition/Psychiatric Neuroimaging, Leiden University Medical Center, Leiden, The Netherlands., Winter-van Rossum I; Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht University, Utrecht, The Netherlands., Luis Ayuso-Mateos J; Department of Psychiatry, Centro de Investigación, Universidad Autónoma de Madrid, Madrid, Spain.; Biomédica en Red de Salud Mental, CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain.; Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-Princesa), Madrid, Spain., R Dawson G; P1vital, Wallingford, Oxfordshire, United Kingdom., Marston H; Boehringer Ingelheim Pharma GmbH & Co KG, CNS Diseases Research, Biberach an der Riss, Germany.; External Neurodegenerative Research, Eli Lilly and Company, Windlesham, United Kingdom., Kas MJH; University of Groningen, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Aug 09; Vol. 19 (8), pp. e0301406. Date of Electronic Publication: 2024 Aug 09 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0301406
Abstrakt: Recently the 1/f signal of human electroencephalography has attracted attention, as it could potentially reveal a quantitative measure of neural excitation and inhibition in the brain, that may be relevant in a clinical setting. The purpose of this short article is to show that the 1/f signal depends on the vigilance state of the brain in both humans and mice. Therefore, proper labelling of the EEG signal is important as improper labelling may obscure disease-related changes in the 1/f signal. We demonstrate this by comparing EEG results from a longitudinal study in a genetic mouse model for synaptic dysfunction in schizophrenia and autism spectrum disorders to results from a large European cohort study with schizophrenia and mild Alzheimer's disease patients. The comparison shows when the 1/f is corrected for vigilance state there is a difference between groups, and this effect disappears when vigilance state is not corrected for. In conclusion, more attention should be paid to the vigilance state during analysis of EEG signals regardless of the species.
Competing Interests: Neetha Das, Hugh Marston and Gerard R. Dawson worked for a company during the data collection of the PRISM1 study. The companies provided support in the form of salaries for authors, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the current manuscript which was performed as a secondary analysis using the PRISM1 data set. The specific roles of these authors are articulated in the ‘author contributions’ section.’ Dr. Arango has been a consultant to or has received honoraria or grants from Acadia, Angelini, Biogen, Boehringer, Gedeon Richter, Janssen Cilag, Lundbeck, Medscape, Menarini, Minerva, Otsuka, Pfizer, Roche, Sage, Servier, Shire, Schering Plough, Sumitomo Dainippon Pharma, Sunovion, Takeda and Teva. The other authors have declared that no competing interests exist.
(Copyright: © 2024 Østergaard et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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