| Autor: |
Fochi RA; Department of Biological Sciences, Institute of Biosciences, Humanities and Exact Sciences- IBILCE, São Paulo State University-UNESP, São Jose´ do Rio Preto, São Paulo, Brazil., Ruiz TFR, Jesus MM, Azevedo LR, Falleiros-Júnior LR, Campos SGP, Góes RM, Oliani SM, Vilamaior PSL, Taboga SR |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of biosciences [J Biosci] 2024; Vol. 49. |
| Abstrakt: |
Paradoxical sleep deprivation (PSD) presents different effects on metabolism and neurological functions. In addition, over long duration, sleep restriction (SR) can promote permanent changes. The prostate is an endocrine-dependent organ with homeostatic regulation directly related to hormone levels. Our study proposed to demonstrate the experimental prostatic effects of PSD (96 h), PSD with recovery (PSR - 96/96 h), and sleep restriction (SR - 30 PSD cycles/recovery). PSD and SR promoted decrease in serum testosterone and significant increase in serum and intraprostatic corticosterone. In agreement, androgen receptors (AR) were less expressed and glucocorticoid receptors (GR) were enhanced in PSR and SR. Thus, the prostate, especially under SR, demonstrates a castration-like effect due to loss of responsiveness and sensitization by androgens. SR triggered an important inflammatory response through enhancement of serum and intraprostatic pro- (IL-1α, IL-6, TNF-α) and anti-inflammatory (IL-10) cytokines. Furthermore, the respective receptors of anti-inflammatory cytokines (IL-1RI and TNF-R) were highly expressed in the prostatic epithelium and stroma. PSR can partially restore prostate homeostasis, as it restores testosterone and the prostate proliferation index, in addition to promoting balance in the inflammatory response that is considered protective. PSD and SR are key factors in the endocrine axis that coordinate prostatic homeostasis, and significant changes in these factors have consequences on prostate functionality. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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