Severity scores, damage indices and the concept of the colchicine-resistant patient in familial Mediterranean fever.

Autor:	Er O; Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine, Istanbul, Turkey., Akay H; Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine, Pathology Department, Istanbul, Turkey., Ozgozen ME; Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine, Istanbul, Turkey., Gulhan D; Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine, Istanbul, Turkey., Ugurlu S; Istanbul University-Cerrahpasa Cerrahpasa Faculty of Medicine, Internal Medicine Department, Rheumatology Division, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Modern rheumatology [Mod Rheumatol] 2024 Aug 09. Date of Electronic Publication: 2024 Aug 09.
DOI:	10.1093/mr/roae067
Abstrakt:	Familial Mediterranean fever (FMF) is a common autoinflammatory disease. The primary treatment is colchicine; however, 5-10% of patients do not respond to colchicine and are considered colchicine resistant. Colchicine resistance and disease severity are highly associated, with each used to assess and define the other. In our review, we examined the most commonly used severity scores, damage indices, and definitions of colchicine resistance, revealing both shortcomings and advantages for each. We emphasize the necessity for a new severity score that integrates the definition of colchicine resistance. (© Japan College of Rheumatology 2024. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site–for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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