Exploring metabolomic dynamics in acute stress disorder: amino acids, lipids, and carbohydrates.

Autor:	Gary NC; Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD, United States.; The Geneva Foundation, Tacoma, WA, United States., Misganaw B; Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD, United States.; Culmen International, Alexandria, VA, United States., Hammamieh R; Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD, United States., Gautam A; Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in genetics [Front Genet] 2024 Jul 25; Vol. 15, pp. 1394630. Date of Electronic Publication: 2024 Jul 25 (Print Publication: 2024).
DOI:	10.3389/fgene.2024.1394630
Abstrakt:	Acute Stress Disorder (ASD) is a psychiatric condition that can develop shortly after trauma exposure. Although molecular studies of ASD are only beginning, groups of metabolites have been found to be significantly altered with acute stress phenotypes in various pre-clinical and clinical studies. ASD implicated metabolites include amino acids (β-hydroxybutyrate, glutamate, 5-aminovalerate, kynurenine and aspartate), ketone bodies (β-hydroxybutyrate), lipids (cortisol, palmitoylethanomide, and N-palmitoyl taurine) and carbohydrates (glucose and mannose). Network and pathway analysis with the most prominent metabolites shows that Extracellular signal-regulated kinases and c-AMP response element binding (CREB) protein can be crucial players. After highlighting main recent findings on the role of metabolites in ASD, we will discuss potential future directions and challenges that need to be tackled. Overall, we aim to showcase that metabolomics present a promising opportunity to advance our understanding of ASD pathophysiology as well as the development of novel biomarkers and therapeutic targets. Competing Interests: Author BM was employed by Culmen International. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Gary, Misganaw, Hammamieh and Gautam.)
Databáze:	MEDLINE
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