Migrainous vertigo impairs adaptive learning as a function of uncertainty.

Autor:	Sharif M; inAmind Laboratory, College of Life Sciences, University of Leicester, Leicester, United Kingdom., Rea O; inAmind Laboratory, College of Life Sciences, University of Leicester, Leicester, United Kingdom., Burling R; inAmind Laboratory, College of Life Sciences, University of Leicester, Leicester, United Kingdom., Ellul Miraval M; inAmind Laboratory, College of Life Sciences, University of Leicester, Leicester, United Kingdom., Patel R; Faculty of Health and Life Sciences, De Monfort University, Leicester, United Kingdom., Saman Y; inAmind Laboratory, College of Life Sciences, University of Leicester, Leicester, United Kingdom., Rea P; E.N.T Department, Leicester Royal Infirmary, Balance Clinic, Leicester, United Kingdom., Yoon HJ; inAmind Laboratory, College of Life Sciences, University of Leicester, Leicester, United Kingdom., Kheradmand A; Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of Otolaryngology and Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States., Arshad Q; inAmind Laboratory, College of Life Sciences, University of Leicester, Leicester, United Kingdom.; Department of Brain Sciences, Centre for Vestibular Neurology, Imperial College, London, United Kingdom.
Jazyk:	angličtina
Zdroj:	Frontiers in neurology [Front Neurol] 2024 Jul 25; Vol. 15, pp. 1436127. Date of Electronic Publication: 2024 Jul 25 (Print Publication: 2024).
DOI:	10.3389/fneur.2024.1436127
Abstrakt:	Objective: In this study, we examined whether vestibular migraine, as a source of increased perceptual uncertainty due to the associated dizziness, interferes with adaptive learning. Methods: The IOWA gambling task (IGT) was used to assess adaptive learning in both healthy controls and patients with migraine-related dizziness. Participants were presented with four decks of cards (A, B, C, and D) and requested to select a card over 100 trials. Participants received a monetary reward or a penalty with equal probability when they selected a card. Card decks A and B (high-risk decks) involved high rewards (win £100) and high penalties (lose £250), whereas C and D (low-risk decks; favorable reward-to-punishment ratio) involved lower rewards (win £50) and penalties (lose £50). Task success required participants to decide (i.e., adaptively learn) through the feedback they received that C and D were the advantageous decks. Results: The study revealed that patients with vestibular migraine selected more high-risk cards than the control group. Chronic vestibular migraine patients showed delayed improvement in task performance than those with acute presentation. Only in acute vestibular migraine patients, we observed that impaired learning positively correlated with measures of dizzy symptoms. Conclusion: The findings of this study have clinical implications for how vestibular migraine can affect behavioural adaption in patients, either directly through altered perception or indirectly by impacting cognitive processes that can result in maladaptive behavior. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Sharif, Rea, Burling, Ellul Miraval, Patel, Saman, Rea, Yoon, Kheradmand and Arshad.)
Databáze:	MEDLINE
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