Reversible Second-Degree Heart Block Attributed to Ondansetron: A Rare Side Effect.
| Autor: | Sebastian A; Internal Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND., Bhaskar E; General Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND., Moorthy S; Internal Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND., M L; Internal Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Jul 08; Vol. 16 (7), pp. e64109. Date of Electronic Publication: 2024 Jul 08 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.64109 |
| Abstrakt: | A primigravida at 36 weeks with gestational diabetes mellitus and hypothyroidism and no prior chronic medical illness was admitted for safe confinement. A cesarean section was required to deliver the baby with breech presentation complicated by a slow progression of labor. Asymptomatic sinus bradycardia with a heart rate of 40 per minute was observed during the induction of anesthesia. Before bupivacaine administration for spinal anesthesia, she was administered pantoprazole 40 mg and ondansetron 4 mg intravenously. ECG recording showed a type 1 Mobitz second-degree heart block. Follow-up ECG showed progression of heart block to type 2 Mobitz second-degree heart block. The second-degree heart block persisted for 16 hours, during which the patient was asymptomatic, and the ventricular rate was maintained at a range of 60-80 per minute. After normalization of rhythm, the patient was observed in the ICU. She received another dose of ondansetron 4 mg intravenously for vomiting, and the heart block recurred. The rhythm disturbance was attributed to ondansetron. Her rhythm normalized after 36 hours, and she was subsequently discharged home three days later. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Sebastian et al.) |
| Databáze: | MEDLINE |
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