A β-Lactamase Responsive Peptide Inhibits MRSA Infection through Self-Assembled Nanonet.

Autor: Wu M; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.; School of Medicine, Shanghai University, Shanghai, 200444, China., Li Y; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.; School of Medicine, Shanghai University, Shanghai, 200444, China., Shen H; School of Medicine, Shanghai University, Shanghai, 200444, China., Zhang Y; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.; School of Medicine, Shanghai University, Shanghai, 200444, China., Cong W; School of Medicine, Shanghai University, Shanghai, 200444, China., Hu X; School of Medicine, Shanghai University, Shanghai, 200444, China., Shi Y; Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China., Hu H; School of Medicine, Shanghai University, Shanghai, 200444, China.; Shanghai Engineering Research Center of Organ Repair, Shanghai, 200444, China.; Shanghai Integration and Innovation Center of Marine Medical Engineering, Shanghai, 200444, China.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Dec; Vol. 13 (31), pp. e2402453. Date of Electronic Publication: 2024 Aug 09.
DOI: 10.1002/adhm.202402453
Abstrakt: Gram-positive S. aureus is one of the leading pathogens for death associated with antimicrobial resistance. The β-lactamase (Bla) secreted by methicillin-resistant S. aureus (MRSA) hydrolyzes nearly all β-lactam antibiotics, leaving only a few antibiotics available for the clinical treatment of MRSA infections. Thereby, a Bla-responsive peptide (BLAP) is designed here with the capacity of inhibiting MRSA infection through mimicking the host defense mechanism of human defensin-6. The BLAP comprising a self-assembling peptide sequence can respond specifically to the secreted Bla and assemble in situ surrounding MRSA. The assembled nanofibrous network is able to trap MRSA, preventing its invasion into the host cells effectively. As a consequence, the intramuscular injection of BLAP significantly restricted bacterial infection and abscess formation in mice. The biomimetic BLAP holds great potential for the efficient treatment of drug-resistant gram-positive bacterial infections.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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