Fusible and Radiopaque Microspheres for Embolization.
Autor: | Li J; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China., Xu J; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China., Wang Y; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China., Chen Y; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China., Ding Y; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China., Gao W; School of Pharmacy, Chengdu University, Chengdu, 610106, China., Tan Y; National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Navy Medical University, Shanghai, 201805, China., Ge N; Intervention Center, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Naval Medical University, Shanghai, 200438, China., Chen Y; National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Navy Medical University, Shanghai, 201805, China., Ge S; National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Navy Medical University, Shanghai, 201805, China., Yang Q; National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Navy Medical University, Shanghai, 201805, China., He B; National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, 610064, China., Ye X; Department of Urology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China. |
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Jazyk: | angličtina |
Zdroj: | Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Sep; Vol. 36 (39), pp. e2405224. Date of Electronic Publication: 2024 Aug 09. |
DOI: | 10.1002/adma.202405224 |
Abstrakt: | In this work, fusible microspheres loaded with radiopaque agents as an embolic agent for transcatheter arterial embolization (TAE) are developed. A poly(ethylene glycol) (PEG) and poly(ε-caprolactone) (PCL) multi-block copolymer basing polyurethane (PCEU) is synthesized and fabricated into blank microspheres (BMs). The microspheres are elastic in compression test. A clinical contrast agent lipiodol is encapsulated in the microspheres to receive fusible radiopaque microspheres (FRMs). The sizes of FRMs are uniform and range from 142.2 to 343.1 µm. The encapsulated lipiodol acts as the plasticizer to reduce the melting temperature point (T (© 2024 Wiley‐VCH GmbH.) |
Databáze: | MEDLINE |
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