The dual nature of T DC - bridging dendritic and T cells in immunity.

Autor: Nelli M; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Kuka M; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation, and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Jazyk: angličtina
Zdroj: FEBS letters [FEBS Lett] 2024 Aug 08. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1002/1873-3468.14998
Abstrakt: T DC are hematopoietic cells with unique features that provide intriguing insights into the interplay between innate and adaptive immunity. They express a combination of conventional dendritic cell (DC) and T-cell markers and are found in secondary lymphoid organs (SLOs), lungs and liver of naïve mice, as well as in human blood. When analyzed ex vivo, T DC can behave either as DCs or as T cells, depending on the provided stimuli. Notably, T DC numbers and activation significantly increase in SLOs following viral infection, suggesting a potential role for T DC in antiviral immune responses. In this review, we discuss the properties of these fascinating cells, which call for more investigation on their physiological role during immune responses to both pathogens and tumors.
(© 2024 The Author(s). FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)
Databáze: MEDLINE
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