Sildenafil-induced priapism in a dog : an unusual case report.

Autor: Nam HS; Dasom Animal Medical Center, 3, Suyeong-ro 13 Beon-gil, Nam-gu, Busan, Republic of Korea.; Department of Veterinary Internal Medicine, College of Veterinary Medicine and Institute for Veterinary Biomedical Science, Kyungpook National University, Daehakro 80, Daegu, 41566, Republic of Korea., Oh YI; Department of Veterinary Internal Medicine, College of Veterinary Medicine and Institute for Veterinary Biomedical Science, Kyungpook National University, Daehakro 80, Daegu, 41566, Republic of Korea. imyein5@knu.ac.kr.
Jazyk: angličtina
Zdroj: BMC veterinary research [BMC Vet Res] 2024 Aug 08; Vol. 20 (1), pp. 352. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1186/s12917-024-04205-6
Abstrakt: Background: Priapism is defined as erection that lasts for more than 4 h without sexual stimulation. There are various causes of priapism, but there are no reports of sildenafil-induced priapism in dogs. In human medicine, there were no pre-marketing reports of priapism caused by sildenafil, but post-marketing surveillance has shown that it is rare. In cases of pulmonary hypertension in dogs, sildenafil is the first-line drug of choice for symptomatic relief.
Case Presentation: An 11-year-old neutered male Maltese dog that presented with tachypnea and cough was diagnosed with myxomatous mitral valve disease, American College of Veterinary Internal Medicine (ACVIM) stage C, and was treated medically. Eighteen months after the diagnosis, severe pulmonary hypertension occurred due to left heart disease. At 20 months postdiagnosis, pleural effusion occurred, and sildenafil (2 mg/kg twice daily) was added to the existing treatment. Two weeks later, the dyspnea recurred, confirming pleural fluid recurrence, and sildenafil was increased to 2 mg/kg thrice daily. One day later, the patient developed persistent erections and penile pain. Penile amputation and urethrostomy were recommended but were refused; therefore, analgesia and palliative care were provided. The patient died of acute dyspnea 22 months after the first presentation, with no specific priapism recurrence at the time of death.
Conclusion: To the best of our knowledge, this is the first report of sildenafil-induced priapism in a dog with pulmonary hypertension.
(© 2024. The Author(s).)
Databáze: MEDLINE
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