Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers.

Autor: Logan JM; Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia. jessica.logan@unisa.edu.au., Martini C; Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia., Sorvina A; Centre for Cancer Biology, University of South Australia, North Terrace, Adelaide, SA, 5000, Australia., Johnson IRD; Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia., Brooks RD; Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia., Caruso MC; Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia., Huzzell C; Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia., Moore CR; Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia., Karageorgos L; Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia., Butler LM; South Australian ImmunoGENomics Cancer Institute and Freemasons Centre for Male Health and Wellbeing, University of Adelaide, Adelaide, SA, 5005, Australia.; Solid Tumour Program, Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia., Tewari P; Department of Histopathology, Trinity College Dublin, D02 PN40, Dublin, Ireland., Prabhakaran S; Department of Anatomical Pathology, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia., Hickey SM; Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia., Klebe S; Department of Anatomical Pathology, College of Medicine and Public Health, Flinders University, Adelaide, SA, 5042, Australia., Samaratunga H; Aquesta Uropathology, The University of Queensland, Brisbane, QLD, 4072, Australia., Delahunt B; Malaghan Institute of Medical Research, Wellington, 6012, New Zealand., Moretti K; Discipline of Surgery, University of Adelaide, Adelaide, SA, 5371, Australia.; Allied Health and Human Performance, University of South Australia, Adelaide, SA, 5005, Australia.; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, 3800, Australia., O'Leary JJ; Department of Histopathology, Trinity College Dublin, D02 PN40, Dublin, Ireland., Brooks DA; Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia., Ung BS; Clinical and Health Sciences, University of South Australia, Bradley Building, City West Campus, North Terrace, Adelaide, SA, 5000, Australia.; Quality Use of Medicines and Pharmacy Research Centre, University of South Australia City East Campus, Frome Rd, Adelaide, SA, 5000, Australia.
Jazyk: angličtina
Zdroj: Scientific data [Sci Data] 2024 Aug 08; Vol. 11 (1), pp. 852. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1038/s41597-024-03696-0
Abstrakt: The diagnosis of prostate cancer using histopathology is reliant on the accurate interpretation of prostate tissue sections. Current standards rely on the assessment of Haematoxylin and Eosin (H&E) staining, which can be difficult to interpret and introduce inter-observer variability. Here, we present a digital pathology atlas and online resource of prostate cancer tissue micrographs for both H&E and the reinterpretation of samples using a novel set of three biomarkers as an interactive tool, where clinicians and scientists can explore high resolution histopathology from various case studies. The digital pathology prostate cancer atlas when used in conjunction with the biomarkers, will assist pathologists to accurately grade prostate cancer tissue samples.
(© 2024. The Author(s).)
Databáze: MEDLINE
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