Central corneal thickness and the risk of primary open-angle glaucoma: a Mendelian randomisation mediation analysis.
| Autor: | Katsimpris A; Department of Ophthalmology, Princess Alexandra Eye Pavilion, Edinburgh, UK., Baumeister SE; Institute of Health Services Research in Dentistry, University of Münster, Münster, Germany., Baurecht H; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany., Tatham AJ; Department of Ophthalmology, Princess Alexandra Eye Pavilion, Edinburgh, UK., Nolde M; Institute of Health Services Research in Dentistry, University of Münster, Münster, Germany nolde@uni-muenster.de. |
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| Jazyk: | angličtina |
| Zdroj: | The British journal of ophthalmology [Br J Ophthalmol] 2024 Dec 17; Vol. 109 (1), pp. 52-57. Date of Electronic Publication: 2024 Dec 17. |
| DOI: | 10.1136/bjo-2023-324996 |
| Abstrakt: | Background: The association of central corneal thickness (CCT) with primary open-angle glaucoma (POAG) remains uncertain. Although several observational studies assessing this relationship have reported an inverse association between CCT and POAG, this could be the result of collider bias. In this study, we leveraged human genetic data to assess through Mendelian randomisation (MR) the effect of CCT on POAG risk and whether this effect is mediated by intraocular pressure (IOP) changes. Methods: We used 24 single-nucleotide polymorphisms (SNPs) associated with CCT (p value<5×10 -8 ) from a genome-wide association study (GWAS) (N=17 803) provided by the International Glaucoma Genetics Consortium and 53 SNPs associated with IOP (p value<5×10 -8 ) from a GWAS of the UK Biobank (UKBB) (N=97 653). We related these instruments to POAG using a GWAS meta-analysis of 8283 POAG cases and 753 827 controls from UKBB and FinnGen. Results: MR analysis suggested a positive association between CCT and POAG (OR of POAG per 50 µm increase in CCT: 1.38; 95% CI: 1.18 to 1.61; p value<0.01). MR mediation analysis showed that 28.4% of the total effect of CCT on POAG risk was mediated through changes in IOP. The primary results were consistent with estimates of pleiotropy-robust MR methods. Conclusion: Contrary to most observational studies, our results showed that a higher CCT is associated with an increased risk of POAG. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.) |
| Databáze: | MEDLINE |
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