Diving into the metabolic interactions of titanium dioxide nanoparticles in "Sparus aurata" and "Ruditapes philippinarum".

Autor: Araújo MJ; CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208, Matosinhos, Portugal. Electronic address: mario.araujo@ciimar.up.pt., Vazquez M; CETGA - Centro Tecnológico del Cluster de la Acuicultura, Punta de Couso s/n, 15965, Ribeira, A Coruña, Spain., Rodriguez-Lorenzo L; INL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330, Braga, Portugal., Moreda-Piñeiro A; GETEE - Trace Element, Spectroscopy and Speciation Group, Institute de Materiais iMATUS. Faculty of Chemistry, University of Santiago de Compostela, Av. das Ciencias s/n, 15782, Santiago de Compostela, Spain., Fonseca E; CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208, Matosinhos, Portugal., Mallo N; CETGA - Centro Tecnológico del Cluster de la Acuicultura, Punta de Couso s/n, 15965, Ribeira, A Coruña, Spain., Pinheiro I; INL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330, Braga, Portugal., Quarato M; INL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330, Braga, Portugal., Bigorra-Ferré E; CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208, Matosinhos, Portugal., Matos A; CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208, Matosinhos, Portugal., Barreiro-Felpeto A; CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208, Matosinhos, Portugal., Turkina MV; Department of Biomedical and Clinical Sciences, Faculty of Medicine and Clinical Sciences, Linköping University, 581 83, Linköping, Sweden., Suárez-Oubiña C; GETEE - Trace Element, Spectroscopy and Speciation Group, Institute de Materiais iMATUS. Faculty of Chemistry, University of Santiago de Compostela, Av. das Ciencias s/n, 15782, Santiago de Compostela, Spain., Bermejo-Barrera P; GETEE - Trace Element, Spectroscopy and Speciation Group, Institute de Materiais iMATUS. Faculty of Chemistry, University of Santiago de Compostela, Av. das Ciencias s/n, 15782, Santiago de Compostela, Spain., Cabaleiro S; CETGA - Centro Tecnológico del Cluster de la Acuicultura, Punta de Couso s/n, 15965, Ribeira, A Coruña, Spain., Vasconcelos V; CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208, Matosinhos, Portugal; FCUP - Biology Department, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, 4169-007, Porto, Portugal., Espiña B; INL - International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330, Braga, Portugal., Campos A; CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208, Matosinhos, Portugal.
Jazyk: angličtina
Zdroj: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2024 Nov 01; Vol. 360, pp. 124665. Date of Electronic Publication: 2024 Aug 06.
DOI: 10.1016/j.envpol.2024.124665
Abstrakt: The biological response to nanomaterials exposure depends on their properties, route of exposure, or model organism. Titanium dioxide nanoparticles (TiO 2 NPs) are among the most used nanomaterials; however, concerns related to oxidative stress and metabolic effects resulting from their ingestion are rising. Therefore, in the present work, we addressed the metabolic effects of citrate-coated 45 nm TiO 2 NPs combining bioaccumulation, tissue ultrastructure, and proteomics approaches on gilthead seabream, Sparus aurata and Japanese carpet shell, Ruditapes philippinarum. Sparus aurata was exposed through artificially contaminated feeds, while R. philippinarum was exposed using TiO 2 NPs-doped microalgae solutions. The accumulation of titanium and TiO 2 NPs in fish liver is associated with alterations in hepatic tissue structure, and alteration to the expression of proteins related to lipid and fatty acid metabolism, lipid breakdown for energy, lipid transport, and homeostasis. While cellular structure alterations and the expression of proteins were less affected than in gilthead seabream, atypical gill cilia and microvilli and alterations in metabolic-related proteins were also observed in the bivalve. Overall, the effects of TiO 2 NPs exposure through feeding appear to stem from various interactions with cells, involving alterations in key metabolic proteins, and changes in cell membranes, their structures, and organelles. The possible appearance of metabolic disorders and the environmental risks to aquatic organisms posed by TiO 2  NPs deserve further study.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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