Burkholderia cenocepacia ST-250 in cystic fibrosis patients in Switzerland: Genomic investigation of transmission routes.

Autor: Zbinden A; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland. Electronic address: andreaczbinden@gmail.com., Seth-Smith HMB; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Beltrami V; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Mancini S; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Droz S; Institute of Infectious Diseases, University of Bern, Bern, Switzerland., Bürgi U; Division of internal Medicine, Service Pulmonology, Cantonal Hospital Lucerne, Lucerne, Switzerland., Melillo D; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Schuurmans MM; Division of Pulmonology, University Hospital Zurich, Zurich, Switzerland., Schwizer B; CF-Center, Quartier Bleu, Lindenhofspital, Bern, Switzerland., Schmid I; CF-Center, Quartier Bleu, Lindenhofspital, Bern, Switzerland., Casaulta C; University Children's Hospital Bern, Bern, Switzerland., Barben J; Paediatric Pulmonology & CF Centre, Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland., Mueller NJ; Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University Zurich, Zurich, Switzerland., Imkamp F; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
Jazyk: angličtina
Zdroj: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2024 Oct; Vol. 110 (2), pp. 116429. Date of Electronic Publication: 2024 Aug 07.
DOI: 10.1016/j.diagmicrobio.2024.116429
Abstrakt: This report describes the characterization of Burkholderia cenocepacia isolates belonging to sequence type (ST)-250, detected in eight patients with cystic fibrosis (CF) in Switzerland. We retrospectively analyzed 18 isolates of B. cenocepacia ST-250 isolated between 2003 and 2015 by whole-genome sequencing and evaluated clinical and epidemiological data. Single nucleotide polymorphism analysis of the B.°cenocepacia ST-250 lineage showed that the isolates from all patients cluster tightly, suggesting that this cluster has a recent common ancestor. Epidemiological investigations showed that six out of eight patients acquired B.°cenocepacia ST-250 in the years 2001-2006, where participation in CF summer camps was common. Two patients were siblings. Genomic relatedness of the B. cenocepacia ST-250 isolates supported transmission by close contact, however, a common source or nosocomial routes cannot be excluded. With respect to the fatal outcome in six patients, our study shows the importance of infection control measurements in CF patients with B.°cenocepacia.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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