Physiology during sleep in preterm infants: Implications for increased risk for the sudden infant death syndrome.

Autor: Horne RS; Department of Paediatrics, Monash University, Melbourne, Australia. Electronic address: rosemary.horne@monash.edu., Harrewijn I; University Hospital Montpellier, France., Hunt CE; Uniformed Services University, Bethesda, MD, USA.
Jazyk: angličtina
Zdroj: Sleep medicine reviews [Sleep Med Rev] 2024 Dec; Vol. 78, pp. 101990. Date of Electronic Publication: 2024 Jul 31.
DOI: 10.1016/j.smrv.2024.101990
Abstrakt: Approximately 15 million babies are born preterm (<37 weeks of completed gestation) worldwide annually. Although neonatal and perinatal medicine have contributed to the increased survival rate of preterm newborn infants, premature infants are at increased risk of mortality in the first years of life. Infants born preterm are at four times the risk of Sudden Infant Death Syndrome (SIDS) compared to infants born at term. SIDS is believed to be multifactorial in origin. The Triple Risk hypothesis has been proposed to explain this. The model suggests that when a vulnerable infant, such as one born preterm, is at a critical but unstable developmental period in homeostatic control, death may occur if exposed to an exogenous stressor, such as being placed prone for sleep. The highest risk period is at ages 2-4 months, with 90 % of deaths occurring before 6 months. The final pathway to SIDS is widely believed to involve some combination of immature cardiorespiratory control and a failure of arousal from sleep. This review will focus on the physiological factors which increase the risk for SIDS in preterm infants and how these factors may be identified and potentially lead to effective preventative strategies.
Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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