Intergenerational effects of maternal childhood maltreatment on newborns' stress regulation: The role of maternal depressive symptoms.

Autor: San Martín-González N; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; Network Centre for Biomedical Research in Mental Health (CIBER-SAM), Carlos III Health Institute, Madrid, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, Spain., Moya-Higueras J; Network Centre for Biomedical Research in Mental Health (CIBER-SAM), Carlos III Health Institute, Madrid, Spain; Department of Psychology, Sociology and Social Work, Faculty of Education, Psychology and Social Work, University of Lleida, Spain., Eixarch E; BCNatal - Fetal Medicine Research Center, Hospital Clínic and Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain; Network Centre for Biomedical Research in Rare Diseases (CIBER-ER), Institute of Health Carlos III, Madrid, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain., Castro-Quintas Á; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; Network Centre for Biomedical Research in Mental Health (CIBER-SAM), Carlos III Health Institute, Madrid, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, Spain., Marques-Feixa L; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; Network Centre for Biomedical Research in Mental Health (CIBER-SAM), Carlos III Health Institute, Madrid, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, Spain., Crispi F; BCNatal - Fetal Medicine Research Center, Hospital Clínic and Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain; Network Centre for Biomedical Research in Rare Diseases (CIBER-ER), Institute of Health Carlos III, Madrid, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain., Daura-Corral M; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain., de la Fuente-Tomás L; Department of Psychology, University of Oviedo, Oviedo, Spain., Monteserín-García JL; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; Network Centre for Biomedical Research in Mental Health (CIBER-SAM), Carlos III Health Institute, Madrid, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, Spain., García-Portilla MP; Network Centre for Biomedical Research in Mental Health (CIBER-SAM), Carlos III Health Institute, Madrid, Spain; Department of Psychiatry, University of Oviedo, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Spain., Fañanás L; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, Barcelona, Spain; Network Centre for Biomedical Research in Mental Health (CIBER-SAM), Carlos III Health Institute, Madrid, Spain; Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona, Spain. Electronic address: lfananas@ub.edu.
Jazyk: angličtina
Zdroj: Child abuse & neglect [Child Abuse Negl] 2024 Sep; Vol. 155, pp. 106968. Date of Electronic Publication: 2024 Aug 07.
DOI: 10.1016/j.chiabu.2024.106968
Abstrakt: Background: Maternal childhood maltreatment (CM) has been repeatedly associated with negative offspring's emotional outcomes. The dysregulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis has emerged as the main underlying physiological mechanism.
Objective: To explore the association between maternal CM and newborns' physiological and neurobehavioral stress responses, considering the role of perinatal maternal depression and bonding.
Participants and Setting: 150 healthy women were followed throughout pregnancy. 79 mother-infant dyads were included in the final analyses. Maternal CM was evaluated using the Childhood Trauma Questionnaire and depressive symptoms by the Edinburgh Postnatal Depression Scale (EPDS) at each trimester. At 7 weeks postpartum, the EPDS and the Postpartum Bonding Questionnaire were administered. Newborns' behavioral responses were assessed using "States Organization" (SO) and "States Regulation" (SR) subdomains of the Neonatal Behavioral Assessment Scale (NBAS). Newborns' salivary samples were collected before and after the NBAS to study cortisol reactivity.
Methods: A cross-lagged panel model was employed.
Results: Infants born to mothers with higher CM presented more optimal scores on SO (β (0.635) = 0.216, p 〈001) and SR (ß (0.273) = 0.195, p = .006), and a higher cortisol reactivity after NBAS handling (β(0.019) = 0.217, p = .009). Moreover, newborns of mothers with higher CM and postpartum depressive symptoms exhibited a poorer performance on SR (ß (0.156 = -0.288,p = .002). Analyses revealed non-significant relationships between mother-infant bonding, newborns' cortisol reactivity and SO.
Conclusions: Newborns from mothers with greater CM present higher cortisol reactivity and more optimal behavioral responses, which may reflect a prenatal HPA axis sensitization. However, those exposed to maternal postnatal depressive symptoms present poorer stress recovery.
Competing Interests: Declaration of competing interest Authors declare no conflict of interest.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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