Factors Associated With Survival Among Patients With Multiple Myeloma in Northeastern Tanzania.

Autor:	Raza FM; Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania., Mkwizu EW; Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.; Cancer Care Centre, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.; Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania., Leak SA; Cancer Care Centre, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.; School of Cancer Sciences, University of Glasgow, Bearsden, Scotland., Sadiq AM; Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.; Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania., Lyamuya FS; Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.; Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania., Chamba NG; Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.; Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania., Kilonzo KG; Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.; Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania., Shao ER; Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.; Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania., Ahmed EA; Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania., Ndale EK; Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.; Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania., Costantine AR; Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.; Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania., Kamabu EM; Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania., Eliah DT; Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.; Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi, Tanzania., Nziku EB; Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania., Henke O; Cancer Care Centre, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.; Section Global Health, University Hospital Bonn, Bonn, Germany.
Jazyk:	angličtina
Zdroj:	JCO global oncology [JCO Glob Oncol] 2024 Aug; Vol. 10, pp. e2400033.
DOI:	10.1200/GO.24.00033
Abstrakt:	Purpose: This study sought to delineate the clinical, laboratory, and imaging characteristics during multiple myeloma (MM) diagnosis, outline the treatment modalities administered, and ascertain the survival rates among patients with MM over a comprehensive 5-year span in Tanzania. Methods: This retrospective cohort study investigated patients diagnosed with MM at the Cancer Care Clinic, Kilimanjaro Christian Medical Centre, between January 2017 and June 2022. Demographic data, clinical profiles, and survival outcomes were collected. The study employed the Kaplan-Meier method to determine overall survival (OS) and survival rates, supported by univariate analysis and a multivariate Cox regression model with significance of P < .05. Results: In this study of 76 patients with MM, bone pain was the most common complaint (76.3%), and patients were age typically older than 50 years (82.5%). Laboratory tests showed frequent abnormalities, such as anemia (51.3%) and hypercalcemia (23.9%). Most patients were at stage III according to Durie Salmon Staging (82.7%), with imaging revealing various bone abnormalities. The median OS was 18.0 months, with 46.1% of patients passing away during the study period. Factors linked to shorter survival included anemia, renal failure, and bone involvement. Infection was the primary cause of death among these patients. The presenting complaint of bone pain significantly affected survival outcomes. Conclusion: This study provides a comprehensive understanding of MM within the Sub-Saharan African context, highlighting age-related disparities in diagnosis, predominant presenting symptoms like bone pain, factors contributing to delayed diagnoses, and the impact on survival rates. The findings underscore the critical need for early recognition, improved diagnostics, and tailored interventions to enhance outcomes for patients with MM in this region.
Databáze:	MEDLINE
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