Characterizing primary transcriptional responses to short term heat shock in Down syndrome.

Autor: Cardiello JF; BioFrontiers Institute, University of Colorado, Boulder, CO, United States of America.; Department of Chemistry & Biochemistry, Colorado College, Colorado Springs, CO, United States of America., Westfall J; Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, United States of America., Dowell R; BioFrontiers Institute, University of Colorado, Boulder, CO, United States of America.; Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, United States of America.; Linda Crnic Institute, University of Colorado, Denver, CO, United States of America.; BioFrontiers-Crnic Boulder Branch, University of Colorado, Boulder, CO, United States of America., Allen MA; BioFrontiers Institute, University of Colorado, Boulder, CO, United States of America.; Linda Crnic Institute, University of Colorado, Denver, CO, United States of America.; BioFrontiers-Crnic Boulder Branch, University of Colorado, Boulder, CO, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Aug 08; Vol. 19 (8), pp. e0307375. Date of Electronic Publication: 2024 Aug 08 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0307375
Abstrakt: Heat shock stress induces genome-wide changes in transcription regulation, activating a coordinated cellular response to enable survival. We noticed many heat shock genes are up-regulated in blood samples from individuals with trisomy 21. We characterized the immediate transcriptional response to heat shock of two lymphoblastoid cell lines derived from brothers with and without trisomy 21. The trisomy 21 cells displayed a more robust heat shock response after just one hour at 42°C than the matched disomic cells.
Competing Interests: RDD and MAA have a patent for “Methods for predicting transcription factor activity” that is not directly related to the work contained in this data note.
(Copyright: © 2024 Cardiello et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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