Accelerated Bone Healing via Electrical Stimulation.

Autor: Sun J; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China., Xie W; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China., Wu Y; School of Kinesiology, Jianghan University, Wuhan, Hubei, 430056, China., Li Z; Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China., Li Y; Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Jazyk: angličtina
Zdroj: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Aug 08, pp. e2404190. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1002/advs.202404190
Abstrakt: Piezoelectric effect produces an electrical signal when stress is applied to the bone. When the integrity of the bone is destroyed, the biopotential within the defect site is reduced and several physiological responses are initiated to facilitate healing. During the healing of the bone defect, the bioelectric potential returns to normal levels. Treatment of fractures that exceed innate regenerative capacity or exhibit delayed healing requires surgical intervention for bone reconstruction. For bone defects that cannot heal on their own, exogenous electric fields are used to assist in treatment. This paper reviews the effects of exogenous electrical stimulation on bone healing, including osteogenesis, angiogenesis, reduction in inflammation and effects on the peripheral nervous system. This paper also reviews novel electrical stimulation methods, such as small power supplies and nanogenerators, that have emerged in recent years. Finally, the challenges and future trends of using electrical stimulation therapy for accelerating bone healing are discussed.
(© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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