Prevention of Ovarian Cancer: Where are We Now and Where are We Going?

Autor: Rodriguez IV; Department of Obstetrics and Gynecology, University of Washington, NE Pacific ST, Box 356460, Seattle, WA, 98195-6460, USA., Ghezelayagh T; Department of Obstetrics and Gynecology, Stanford University, Palo Alto, CA, USA., Pennington KP; Alaska Women's Cancer Care, 3851 Piper St Ste U264, Anchorage, AK, 99508, USA., Norquist BM; Department of Obstetrics and Gynecology, University of Washington, NE Pacific ST, Box 356460, Seattle, WA, 98195-6460, USA. bnorquis@uw.edu.
Jazyk: angličtina
Zdroj: Current oncology reports [Curr Oncol Rep] 2024 Aug 08. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1007/s11912-024-01587-6
Abstrakt: Purpose of Review: To describe current and future strategies to reduce the burden of ovarian cancer through prevention.
Recent Findings: Current strategies in genetic testing are missing a substantial number of individuals at risk, representing a missed opportunity for ovarian cancer prevention. Past efforts at screening and early detection have thus far failed to improve ovarian cancer mortality, and novel techniques are needed. Surgical prevention is highly effective, but surgical menopause from oophorectomy has significant side effects. Novel surgical strategies aimed at reducing risk while minimizing these harms are currently being studied. To maximize ovarian cancer prevention, a multi-pronged approach is needed. We propose that more inclusive and accurate genetic testing to identify more individuals at risk, novel molecular screening and early detection, surgical prevention that maximizes quality of life while reducing risk, and broader adoption of targeted and opportunistic salpingectomy will together reduce the burden of ovarian cancer.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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