The Effect of Low-Dose Colchicine on the Phenotype and Function of Neutrophils and Monocytes in Patients with Chronic Coronary Artery Disease: A Double-Blind Randomized Placebo-Controlled Cross-Over Study.

Autor: Tercan H; Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands., van Broekhoven A; Department of Cardiology, Radboud University Medical Centre, Nijmegen, The Netherlands., Bahrar H; Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands., Opstal T; Department of Cardiology, Radboud University Medical Centre, Nijmegen, The Netherlands.; Department of Cardiology, Northwest Clinics, Alkmaar, The Netherlands., Cossins BC; Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands., Rother N; Department of Nephrology, Radboud University Medical Centre, Nijmegen, The Netherlands., Rodwell L; Section Biostatistics, IQ Health, Radboud University Medical Center, Nijmegen, The Netherlands., Bekkering S; Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands., El Messaoudi S; Department of Cardiology, Radboud University Medical Centre, Nijmegen, The Netherlands., Riksen NP; Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands., Cornel JH; Department of Cardiology, Radboud University Medical Centre, Nijmegen, The Netherlands.; Department of Cardiology, Northwest Clinics, Alkmaar, The Netherlands.; Dutch Network for Cardiovascular Research (WCN), Utrecht, The Netherlands.
Jazyk: angličtina
Zdroj: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 Nov; Vol. 116 (5), pp. 1325-1333. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1002/cpt.3394
Abstrakt: Recent landmark trials showed that colchicine provides a substantial benefit in reducing major cardiovascular events in patients with coronary artery disease. Yet, its exact mechanism of action is still poorly understood. This study aimed to unravel the effect of colchicine on monocyte and neutrophil phenotype and function. A randomized double-blind placebo-controlled cross-over intervention study was executed in patients with a history of myocardial infarction. In neutrophils, colchicine treatment decreased CD62L expression and NGAL release upon ex vivo stimulation and increased PMA-induced ROS production. The effects of colchicine on monocytes were limited to a decrease in HLA-DR expression in the intermediate and nonclassical monocytes. Also, on the level of RNA expression, colchicine did not affect monocyte phenotype, while affecting various immunomodulating genes in neutrophils. Overall, our study suggests that treatment with colchicine affects neutrophil function, particularly by reducing neutrophil recruitment, lowering concentrations of NGAL, and changing the expression of various genes with immunomodulatory potential, whereas the effect on monocytes is limited.
(© 2024 The Author(s). Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.)
Databáze: MEDLINE
Externí odkaz: