Validation of MLC leaf open time calculation methods for PSQA in adaptive radiotherapy with tomotherapy units.

Autor: Nasrallah M; Institute of Radiation Physics, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland., Bochud F; Institute of Radiation Physics, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland., Tellapragada N; Accuray Incorporated, Madison, Wisconsin, USA., Bourhis J; Radiation Oncology Department, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland., Chao E; Accuray Incorporated, Madison, Wisconsin, USA., Casey D; Accuray Incorporated, Madison, Wisconsin, USA., Moeckli R; Institute of Radiation Physics, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Jazyk: angličtina
Zdroj: Journal of applied clinical medical physics [J Appl Clin Med Phys] 2024 Oct; Vol. 25 (10), pp. e14478. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1002/acm2.14478
Abstrakt: Background: Treatment delivery safety and accuracy are essential to control the disease and protect healthy tissues in radiation therapy. For usual treatment, a phantom-based patient specific quality assurance (PSQA) is performed to verify the delivery prior to the treatment. The emergence of adaptive radiation therapy (ART) adds new complexities to PSQA. In fact, organ at risks and target volume re-contouring as well as plan re-optimization and treatment delivery are performed with the patient immobilized on the treatment couch, making phantom-based pretreatment PSQA impractical. In this case, phantomless PSQA tools based on multileaf collimator (MLC) leaf open times (LOTs) verifications provide alternative approaches for the Radixact® treatment units. However, their validity is compromised by the lack of independent and reliable methods for calculating the LOT performed by the MLC during deliveries.
Purpose: To provide independent and reliable methods of LOT calculation for the Radixact® treatment units.
Methods: Two methods for calculating the LOTs performed by the MLC during deliveries have been implemented. The first method uses the signal recorded by the build-in detector and the second method uses the signal recorded by optical sensors mounted on the MLC. To calibrate the methods to the ground truth, in-phantom ionization chamber LOT measurements have been conducted on a Radixact® treatment unit. The methods were validated by comparing LOT calculations with in-phantom ionization chamber LOT measurements performed on two Radixact® treatment units.
Results: The study shows a good agreement between the two LOT calculation methods and the in-phantom ionization chamber measurements. There are no notable differences between the two methods and the same results were observed on the different treatment units.
Conclusions: The two implemented methods have the potential to be part of a PSQA solution for ART in tomotherapy.
(© 2024 The Author(s). Journal of Applied Clinical Medical Physics is published by Wiley Periodicals, Inc. on behalf of The American Association of Physicists in Medicine.)
Databáze: MEDLINE
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