Role of ursolic acid in preventing gastrointestinal cancer: recent trends and future perspectives.

Autor:	Chauhan A; Amity Institute of Environmental Toxicology Safety and Management, Amity University, Noida, Uttar Pradesh, India., Pathak VM; Parwatiya Shiksha Sabha (PASS), Haldwani, India., Yadav M; Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India., Chauhan R; Department of Biotechnology, Graphic Era Deemed to be University, Dehradun, Uttarakhand, India., Babu N; Department of Microbiology, Baba Farid Institute of Technology, Dehradun, Uttarakhand, India., Chowdhary M; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India., Ranjan A; Academy of Biology and Biotechnology, Southern Federal University, Rostov-on-Don, Russia., Mathkor DM; Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi Arabia., Haque S; Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi Arabia.; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, Lebanon., Tuli HS; Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Ambala, India., Ramniwas S; University Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Mohali, India., Yadav V; Department of Translational Medicine, Clinical Research Centre, Skåne University Hospital, Lund University, Malmö, Sweden.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2024 Jul 24; Vol. 15, pp. 1405497. Date of Electronic Publication: 2024 Jul 24 (Print Publication: 2024).
DOI:	10.3389/fphar.2024.1405497
Abstrakt:	Gastrointestinal malignancies are one of the major worldwide health concerns. In the present review, we have assessed the plausible therapeutic implication of Ursolic Acid (UA) against gastrointestinal cancer. By modulating several signaling pathways critical in cancer development, UA could offer anti-inflammatory, anti-proliferative, and anti-metastatic properties. However, being of low oral bioavailability and poor permeability, its clinical value is restricted. To deliver and protect the drug, liposomes and polymer micelles are two UA nanoformulations that can effectively increase medicine stability. The use of UA for treating cancers is safe and appropriate with low toxicity characteristics and a predictable pharmacokinetic profile. Although the bioavailability of UA is limited, its nanoformulations could emerge as an alternative to enhance its efficacy in treating GI cancers. Further optimization and validation in the clinical trials are necessary. The combination of molecular profiling with nanoparticle-based drug delivery technologies holds the potential for bringing UA to maximum efficacy, looking for good prospects with GI cancer treatment. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Chauhan, Pathak, Yadav, Chauhan, Babu, Chowdhary, Ranjan, Mathkor, Haque, Tuli, Ramniwas and Yadav.)
Databáze:	MEDLINE
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