Associations of bisphenol and phthalate exposure and anti-Müllerian hormone levels in women of reproductive age.

Autor:	Blaauwendraad SM; The Generation R Study Group, Erasmus Medical Center (MC), University Medical Center, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Dykgraaf RHM; Department of Obstetrics and Gynecology, Erasmus Medical Centre, Rotterdam, the Netherlands., Gaillard R; The Generation R Study Group, Erasmus Medical Center (MC), University Medical Center, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Liu M; Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.; New York University College of Global Public Health, New York University, New York, NY, USA., Laven JS; Department of Obstetrics and Gynecology, Erasmus Medical Centre, Rotterdam, the Netherlands., Jaddoe VWV; The Generation R Study Group, Erasmus Medical Center (MC), University Medical Center, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands., Trasande L; Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.; New York University College of Global Public Health, New York University, New York, NY, USA.
Jazyk:	angličtina
Zdroj:	EClinicalMedicine [EClinicalMedicine] 2024 Jul 17; Vol. 74, pp. 102734. Date of Electronic Publication: 2024 Jul 17 (Print Publication: 2024).
DOI:	10.1016/j.eclinm.2024.102734
Abstrakt:	Background: In women, exposure to endocrine disrupting chemicals might accelerate the depletion of the ovarian reserve and might be associated with accelerative reproductive aging and fertility. We examined the longitudinal associations of exposure to bisphenols and phthalates with anti-Müllerian hormone concentrations. Methods: Pregnant women of 18 years or older that resided in Rotterdam between 2002 and 2006 were eligible for participation in this longitudinal prospective cohort study. We measured urinary bisphenol and phthalate concentration at three time-points in pregnancy among 1405 women, of whom 1322 women had serum Anti-Müllerian Hormone (AMH) measurements 6 and/or 9 years postpartum. We performed linear regression models to assess the association of urinary bisphenol and phthalate metabolites with AMH after 6 and 9 years, and linear mixed-effect model to assess the association with AMH over time. Models were adjusted for sociodemographic and lifestyle factors. Findings: In our multivariable linear regression models we observed associations of higher urinary pregnancy-averaged mono-isobutyl phthalate (mIBP), mono-(2-ethyl-5-oxohexyl) phthalate (mEOHP), and monobenzyl phthalate (mBzBP) with lower serum AMH after both 6 and 9 years. However, these associations did not remain after adjustment for multiple testing. No significant associations of bisphenol A with AMH were present in our study sample. In our linear mixed-effects models, higher mIBP, mono-(2-ethyl-5-hydroxyhexyl) phthalate (mEHHP), mEOHP, and mBzBP were associated with lower overall AMH levels (differences -0.07 (95% CI -0.13, -0.02), -0.09 (-0.15, -0.02), -0.08 (95% CI -0.14, -0.02), and -0.08 (-0.13, -0.03) μg/L per doubling in mIBP, mEHHP, mEOHP, and mBzBP respectively) (all False Discovery Rate adjusted p-values < 0.05). Interpretation: We identify decreases in indices of ovarian reserve in relationship to prenatal phthalate exposures. Studies are needed replicating our results among large multi-ethnic non-pregnant populations and assessing transgenerational effects of exposure on ovarian reserve. Funding: This study was supported by the Erasmus Medical Center and Erasmus University Rotterdam, the Netherlands Organisation for Health Research and Development, the European Research Council, the Dutch Heart Foundation, the Dutch Diabetes Foundation, the European Union's Horizon 2020 Research and Innovation Program, the National Institutes of Health, Ansh Labs Webster, and the Royal Netherlands Academy of Arts and Sciences. Competing Interests: SMB is supported by the Royal Netherlands Academy of Arts and Sciences. JSL declares grants from Ferring Pharmaceuticals and Merck, consulting fees from Ferring Pharmaceuticals and Gedeon Richter, honoraria for lectures and support for attending meetings from Ferring Pharmaceuticals, participation to the advisory board of LOCI Trial UK, and is president of the AE PCOS society. LT is supported by the National Institute of Environmental Health Sciences. All other authors declare no conflict of interest. (© 2024 The Author(s).)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu