Exploring Genetic Link of Residual Ridge Resorption in Completely Edentulous Individuals: A Prospective Case-Control Clinical Study.

Autor:	Nagarajan M; Department of Prosthodontics and Crown and Bridge, Government Dental College and Hospital, Cuddalore, IND., Dayasekaran V; Department of Prosthodontics and Crown and Bridge, Government Dental College and Hospital, Cuddalore, IND., Jayavel K; Department of Periodontics and Implantology, Government Dental College and Hospital, Cuddalore, IND., Jayaraj M; Department of Oral and Maxillofacial Pathology, Chettinad Dental College and Research Institute, Chennai, IND., Chellaswamy S; Department of Oral and Maxillofacial Pathology, Chettinad Dental College and Research Institute, Chennai, IND., Ranganathan K; Department of Prosthodontics and Crown and Bridge, Government Dental College and Hospital, Cuddalore, IND., Kaliamoorthy S; Department of Dentistry, Vinayaka Mission's Medical College and Hospital, Vinayaka Mission's Research Foundation (DU), Karaikal, IND., Chellapandi S; Department of Periodontics, Chettinad Dental College and Research Institute, Chennai, IND., Baskaran R; Department of Periodontics, Chettinad Dental College and Research Institute, Chennai, IND., Elumalai A; Department of Periodontics, Chettinad Dental College and Research Institute, Chennai, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jul 07; Vol. 16 (7), pp. e64039. Date of Electronic Publication: 2024 Jul 07 (Print Publication: 2024).
DOI:	10.7759/cureus.64039
Abstrakt:	Background: Residual ridge resorption presents obstacles in prosthodontic treatment, affecting denture stability and the success of dental implants. Genetic elements, specifically the single nucleotide polymorphism (SNP) 1772C>T variant within the hypoxia-inducible factor 1 subunit alpha (HIF-1α) gene, are hypothesized to contribute to residual ridge resorption progression. Nevertheless, its impact remains insufficiently investigated, especially within the context of South Indian populations. We sought to investigate the connection between SNP 1772C>T and residual ridge resorption (RRR) among fully edentulous individuals, considering demographic factors, genotyping methodologies, and statistical evaluations. Methods: In a prospective case-control study, we recruited 100 completely edentulous participants from South India. Participants were categorized based on alveolar ridge height. Saliva samples were non-invasively collected for DNA extraction, and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was employed to determine genotype distribution using the HphI restriction enzyme. The statistical evaluations comprised the utilization of chi-square and Fisher's exact tests. Results: We observed no significant variations in genotype distributions between the case and control cohorts (CT: p=0.24; CC: p=0.65; TT: p=0.30). The heterozygous genotype CT was prevalent in both groups. Conclusions: Although we did not observe significant associations between SNP 1772C>T and RRR, our findings imply a genetic predisposition to residual ridge resorption that warrants further exploration. Variations in genetic susceptibility across ethnicities and the influence of other genetic variants on residual ridge resorption require additional investigation. This study lays the groundwork for personalized prosthodontic care by highlighting the potential of genetic analysis in routine dental practice to improve treatment strategies. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Institutional Ethical Committee of Government Dental College and Hospital, Cuddalore issued approval #IHEC/865/2022. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Nagarajan et al.)
Databáze:	MEDLINE
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