[The association of single-nucleotide polymorphism rs6265 of the brain-derived neurotrophic factor gene with clinical features in Parkinson's disease].

Autor:	Nikitina MA; Siberian State Medical University, Tomsk, Russia., Bragina EY; Scientific Research Institute of Medical Genetics - Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia., Nazarenko MS; Siberian State Medical University, Tomsk, Russia.; Scientific Research Institute of Medical Genetics - Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia., Alifirova VM; Siberian State Medical University, Tomsk, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2024; Vol. 124 (7), pp. 82-88.
DOI:	10.17116/jnevro202412407182
Abstrakt:	Objective: To evaluate the frequency and severity of various clinical symptoms of Parkinson's disease (PD) depending on the BDNF rs6265 polymorphism. Material and Methods: The study included 533 patients with PD. The stage of PD was assessed using the Hoehn and Yahr scale (1967), motor symptoms were evaluated with MDS-UPDRS. Assessment of non-motor symptoms (NMS) in PD was conducted using the Beck Depression Inventory II (BDI-II); the Hospital Anxiety and Depression Scale (HADS); the Apathy Scale; the Montreal Cognitive Assessment (MoCA test); the Questionnaire for Impulsive-Compulsive Disorders in PD -Rating Scale (QUIP-RS). Genotyping of the BDNF variant (rs6265) was performed using real-time PCR with TaqMan probes. Results: Most PD patients have a combination of NMS increasing as the disease progresses and is determined by molecular-genetic individual characteristics. There are significant differences in the severity of motor symptoms and NMS: individuals with the AA genotype showed significantly pronounced motor symptoms ( p <0.0001); emotional-affective symptoms ( p <0.0001); cognitive and impulsive behavioral disorders ( p <0.0001). Conclusion: The rs6265 BDNF allele A is associated with a wide range of NMS, increasing the risk of their development in patients with PD, thus playing the important role in the etiopathogenesis of this pathology.
Databáze:	MEDLINE
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