Multisensory gamma stimulation mitigates the effects of demyelination induced by cuprizone in male mice.

Autor: Rodrigues-Amorim D; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Bozzelli PL; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Kim T; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Liu L; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Gibson O; Biomage, Ltd, 30 Queensferry Road, Edinburgh, UK., Yang CY; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Murdock MH; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Galiana-Melendez F; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Schatz B; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Davison A; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Islam MR; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Shin Park D; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Raju RM; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Newborn Medicine, Harvard Medical School, Boston Children's Hospital, Boston, MA, USA., Abdurrob F; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA., Nelson AJ; Cell Signaling Technology, 3 Trask Lane, Danvers, MA, USA., Min Ren J; Cell Signaling Technology, 3 Trask Lane, Danvers, MA, USA., Yang V; Cell Signaling Technology, 3 Trask Lane, Danvers, MA, USA., Stokes MP; Cell Signaling Technology, 3 Trask Lane, Danvers, MA, USA., Tsai LH; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA. lhtsai@mit.edu.; Broad Institute of Harvard and MIT, Cambridge, MA, USA. lhtsai@mit.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Aug 08; Vol. 15 (1), pp. 6744. Date of Electronic Publication: 2024 Aug 08.
DOI: 10.1038/s41467-024-51003-7
Abstrakt: Demyelination is a common pathological feature in a wide range of diseases, characterized by the loss of myelin sheath and myelin-supporting oligodendrocytes. These losses lead to impaired axonal function, increased vulnerability of axons to damage, and result in significant brain atrophy and neuro-axonal degeneration. Multiple pathomolecular processes contribute to neuroinflammation, oligodendrocyte cell death, and progressive neuronal dysfunction. In this study, we use the cuprizone mouse model of demyelination to investigate long-term non-invasive gamma entrainment using sensory stimulation as a potential therapeutic intervention for promoting myelination and reducing neuroinflammation in male mice. Here, we show that multisensory gamma stimulation mitigates demyelination, promotes oligodendrogenesis, preserves functional integrity and synaptic plasticity, attenuates oligodendrocyte ferroptosis-induced cell death, and reduces brain inflammation. Thus, the protective effects of multisensory gamma stimulation on myelin and anti-neuroinflammatory properties support its potential as a therapeutic approach for demyelinating disorders.
(© 2024. The Author(s).)
Databáze: MEDLINE
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