Single gene mutations and prognosis in limited-stage follicular lymphoma treated with radiation therapy.

Autor: Hershenfeld SA; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Tobin JWD; Mater Research University of Queensland, Brisbane, Queensland, Australia.; Department of Haematology, Princess Alexandra Hospital, Brisbane, Queensland, Australia., Shelton V; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Calvente L; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Lajkosz K; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Liu T; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Brodtkorb M; Department of Oncology, Oslo University Hospital, Oslo, Norway., d'Amore FA; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark., Ludvigsen M; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Baetz T; Queen's University, Kingston, Ontario, Canada., LeBrun D; Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada., Johnson N; Departments of Medicine and Oncology, Jewish General Hospital, Montreal, Quebec, Canada., Crump M; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Hong M; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Kuruvilla J; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Tremblay-LeMay R; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., MacManus M; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Tsang R; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Hodgson DC; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Gandhi MK; Mater Research University of Queensland, Brisbane, Queensland, Australia.; Department of Haematology, Princess Alexandra Hospital, Brisbane, Queensland, Australia., Kridel R; Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.
Jazyk: angličtina
Zdroj: British journal of haematology [Br J Haematol] 2024 Nov; Vol. 205 (5), pp. 1810-1814. Date of Electronic Publication: 2024 Aug 07.
DOI: 10.1111/bjh.19698
Abstrakt: Radiotherapy is routinely used for management of limited-stage follicular lymphoma (FL), yet half of patients ultimately relapse. We hypothesized that the presence of specific gene mutations may predict outcomes. We performed targeted sequencing of a 69-gene panel in 117 limited-stage FL patients treated with radiotherapy and identified recurrently mutated genes. CREBBP was most frequently mutated, and mutated CREBBP was associated with inferior progression-free survival, though not after false discovery rate adjustment. This association failed to validate in an independent cohort. We conclude that recurrent gene mutations do not predict outcomes in this setting. Alternative biomarkers may offer better prognostic insight.
(© 2024 The Author(s). British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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