Medical comorbidities and lower myelin content are associated with poor cognition in young adults with perinatally acquired HIV.

Autor:	Patel PB; University of Washington, Seattle, Washington., Prince DK; University of Washington, Seattle, Washington., Bolenzius J; Missouri Institute of Mental Health, University of Missouri, St. Louis, Missouri., Ch'en P; University of Washington, Seattle, Washington., Chiarella J; Yale University, New Haven, Connecticut., Kolind S; University of British Columbia, Vancouver, British Columbia, USA., Vavasour I; University of British Columbia, Vancouver, British Columbia, USA., Pedersen T; University of Washington, Seattle, Washington., Levendovszky SR; University of Washington, Seattle, Washington., Spudich S; Yale University, New Haven, Connecticut., Marra C; University of Washington, Seattle, Washington., Paul R; Missouri Institute of Mental Health, University of Missouri, St. Louis, Missouri.
Jazyk:	angličtina
Zdroj:	AIDS (London, England) [AIDS] 2024 Nov 15; Vol. 38 (14), pp. 1932-1939. Date of Electronic Publication: 2024 Aug 07.
DOI:	10.1097/QAD.0000000000003989
Abstrakt:	Objective: Approximately 40% of adults living with HIV experience cognitive deficits. Little is known about the risk factors for cognitive impairment and its association with myelin content in young adults living with perinatally acquired HIV (YApHIV), which is assessed in our cross-sectional study. Design: A prospective, observational cohort study. Methods: All participants underwent an 11-test cognitive battery and completed medical and social history surveys. Cognitive impairment was defined as Z scores falling at least 1.5 SD below the mean in at least two domains. Twelve participants underwent myelin water imaging. Neuroimaging data were compared to age and sex-matched HIV-uninfected controls. Regression analyses were used to evaluate for risk factors of lower cognitive domain scores and association between myelin content and cognition in YApHIV. Results: We enrolled 21 virally suppressed YApHIV across two sites in the United States. Ten participants (48%) met criteria for cognitive impairment. Participants with any non-HIV related medical comorbidity scored lower across multiple cognitive domains compared to participants without comorbidities. Myelin content did not differ between YApHIV and controls after adjusting for years of education. Lower cognitive scores were associated with lower myelin content in the cingulum and corticospinal tract in YApHIV participants after correcting for multiple comparisons. Conclusion: Poor cognition in YApHIV may be exacerbated by non-HIV related comorbidities as noted in older adults with horizontally acquired HIV. The corticospinal tract and cingulum may be vulnerable to the legacy effect of untreated HIV in infancy. Myelin content may be a marker of cognitive reserve in YApHIV. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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