A Cross-Sectional Study of Health-Related Quality of Life in Patients with Predominantly Antibody Deficiency.

Autor: Elmoursi A; Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, MGH Allergy Associates, Yawkey 4B, Boston, Massachusetts, 02114, USA.; Harvard Medical School, Boston, Massachusetts, USA., Zhou B; Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, MGH Allergy Associates, Yawkey 4B, Boston, Massachusetts, 02114, USA., Ong MS; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA., Hong JS; Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, MGH Allergy Associates, Yawkey 4B, Boston, Massachusetts, 02114, USA., Pak A; Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, MGH Allergy Associates, Yawkey 4B, Boston, Massachusetts, 02114, USA., Tandon M; Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, MGH Allergy Associates, Yawkey 4B, Boston, Massachusetts, 02114, USA., Sutherland N; Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, MGH Allergy Associates, Yawkey 4B, Boston, Massachusetts, 02114, USA., DiGiacomo DV; Department of Pediatrics, K. Hovnanian Children's Hospital, Jersey Shore University Medical Center, Neptune, New Jersey, USA.; Hackensack Meridian School of Medicine, Nutley, New Jersey, USA., Farmer JR; Program in Clinical Immunodeficiency, Division of Allergy and Immunology, Beth Israel Lahey Health, Burlington, Massachusetts, USA., Barmettler S; Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, MGH Allergy Associates, Yawkey 4B, Boston, Massachusetts, 02114, USA. sbarmettler@mgh.harvard.edu.; Harvard Medical School, Boston, Massachusetts, USA. sbarmettler@mgh.harvard.edu.
Jazyk: angličtina
Zdroj: Journal of clinical immunology [J Clin Immunol] 2024 Aug 07; Vol. 44 (8), pp. 173. Date of Electronic Publication: 2024 Aug 07.
DOI: 10.1007/s10875-024-01781-y
Abstrakt: Health-related quality of life (HRQoL) measures individual well-being across physical, psychological, and social domains. Patients with predominantly antibody deficiency (PAD) are at risk for morbidity and mortality, however, the effect of these complications on HRQoL requires additional study. Patients with PAD were asked to voluntarily complete the Centers for Disease Control (CDC) HRQoL-14 Healthy Days Measure questionnaire. These results were compared to data from the CDC-initiated Behavioral Risk Factor Surveillance System (BRFSS), a cross-sectional questionnaire including questions from CDC-HRQOL-14. Statistical analyses included two-proportion Z-test, t-tests, and analysis of variance. 83 patients with PAD completed the survey. Patients were sub-stratified into mild (23.7%), moderate (35.5%), severe (40.8%), and secondary (8.4%) PAD. "Fair or poor" health status was reported in 52.6% of PAD patients. Mental health challenges ≥ 14 days/month occurred in 25% of patients. Physical health issues ≥ 14 days/month was reported in 44.7% of patients. Activity limitations were noted by 80.3% of patients. There were no statistically significant differences by PAD severity. Patients with autoimmune and inflammatory disease co-morbidities reported more mental health challenges compared to those without (78% vs. 54.3%, p = 0.02). Compared to the CDC-BRFSS data, significantly more patients with PAD reported "fair or poor" health status (53% vs 12.0%; p < 0.0001), mental health challenges (24.1% vs 14.7%; p = 0.02), and poor physical health (44.6% vs 8.0%; p < 0.0001). Patients with PAD had significantly reduced HRQoL compared to CDC-BRFSS respondents from a similar geographical region. Decreased HRQoL was prevalent across all PAD severity levels. Additional research is needed to improve HRQoL for patients with PAD.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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