| Autor: |
Walsh T; Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada. makbari@uvic.ca.; Center for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, Victoria, BC V8W 2Y2, Canada., Hadisi Z; Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada. makbari@uvic.ca.; Center for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, Victoria, BC V8W 2Y2, Canada., Dabiri SMH; Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada. makbari@uvic.ca.; Center for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, Victoria, BC V8W 2Y2, Canada., Hasanpour S; Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada. makbari@uvic.ca.; Center for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, Victoria, BC V8W 2Y2, Canada., Samimi S; Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada. makbari@uvic.ca.; Center for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, Victoria, BC V8W 2Y2, Canada., Azimzadeh M; Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada. makbari@uvic.ca.; Center for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, Victoria, BC V8W 2Y2, Canada., Akbari M; Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada. makbari@uvic.ca.; Center for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, Victoria, BC V8W 2Y2, Canada. |
| Abstrakt: |
Theranostic sutures are derived from innovative ideas to enhance wound healing results by adding wound diagnostics and therapeutics to typical sutures by functionalizing them with additional materials. Here, we present a new direct electrospinning method for the fast, continuous, inexpensive, and high-throughput production of versatile nanofibrous-coated suture threads, with precise control over various essential microstructural and physical characteristics. The thickness of the coating layer and the alignment of nanofibers with the thread's direction can be adjusted by the user by varying the spooling speed and the displacement between the spinneret needle and thread. To show the flexibility of our method for a range of different materials selected, gelatin, polycaprolactone, silk fibroin, and PEDOT:PSS (poly(3,4-ethylene dioxythiophene):poly(styrene sulfonate)) were the resultant nanofibers characterized by scanning electron microscopy (SEM) imaging and conductivity tests. In a series of in vitro and ex vivo tests (pig skin), sutures were successfully tested for their flexibility and mechanical properties when used as weaving and knotting sutures, and their biocompatibility with a keratinocyte cell line. For temperature-based drug-releasing tests, two fluorescent molecules as drug models with high and low molecular weight, namely fluorescein isothiocyanate-dextran (20 kDa) and rhodamine B (470 Da), were used, and their steady release with incremental increase of temperature to 37 °C over 120 min was seen, which is appropriate for bacterial treatment drugs. Given the advantages of the presented technique, it seems to have promising potential to be used in future medical applications for wound closure and bacterial infection treatment via a temperature-triggered drug release strategy. |
