Global Leadership Initiative on Malnutrition cachexia: an inflammation-first approach for the diagnosis of disease-related malnutrition.
| Autor: | McGovern J; Academic Unit of Surgery, University of Glasgow, Glasgow., Skipworth RJE; Clinical Surgery, Royal Infirmary of Edinburgh., Laird BJA; Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., McMillan DC; Academic Unit of Surgery, University of Glasgow, Glasgow. |
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| Jazyk: | angličtina |
| Zdroj: | Current opinion in clinical nutrition and metabolic care [Curr Opin Clin Nutr Metab Care] 2024 Sep 01; Vol. 27 (5), pp. 393-396. Date of Electronic Publication: 2024 Aug 08. |
| DOI: | 10.1097/MCO.0000000000001052 |
| Abstrakt: | Purpose of Review: The following article examines the rationale for an inflammation-first approach for diagnosing cachexia and how the current Global Leadership Initiative on Malnutrition (GLIM) framework may be adapted to facilitate this. Recent Findings: Recently, the GLIM have published guidance on the measurement of inflammation in the context of cachexia, advocating that C-reactive protein (CRP) should be utilized for quantification. The inclusion of a systemic inflammatory biomarker for the diagnosis of cachexia questions whether it may be more aptly considered a systemic inflammatory syndrome. Summary: The current consensus of the GLIM is that cachexia is 'disease-related malnutrition with inflammation'. In line with this definition, the GLIM proposed a two-step diagnostic framework: screening for malnutrition using validated screening tools and then confirming the presence of disease-related malnutrition with phenotypic (nonvolitional weight loss, low BMI, and reduced muscle mass) and aetiologic criterion reduced food intake/assimilation, and inflammation or disease burden). The GLIM are to be commended for guidance on the measurement of systemic inflammation in their current proposal, given the relative importance to clinical outcomes in patients with cancer. However, the use of CRP is somewhat rudimentary and contrasts other cancer cachexia guidelines and contemporary clinical cancer research. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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