| Autor: |
Soggia G; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain., ElMaghloob Y; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.; Systems Biology and Immunology Lab, Children's Cancer Hospital Egypt, Cairo, Egypt., Boromangnaeva AK; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain., Al Jord A; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain. |
| Abstrakt: |
Organism health relies on cell proliferation, migration, and differentiation. These universal processes depend on cytoplasmic reorganization driven notably by the cytoskeleton and its force-generating motors. Their activity generates forces that mechanically agitate the cell nucleus and its interior. New evidence from reproductive cell biology revealed that these cytoskeletal forces can be tuned to remodel nuclear membraneless compartments, known as biomolecular condensates, and regulate their RNA processing function for the success of subsequent cell division that is critical for fertility. Both cytoskeletal and nuclear condensate reorganization are common to numerous physiological and pathological contexts, raising the possibility that mechanical remodeling of nuclear condensates may be a much broader mechanism regulating their function. Here, we review this newfound mechanism of condensate remodeling and venture into the contexts of health and disease where it may be relevant, with a focus on reproduction, cancer, and premature aging. |
