A pre-vertebrate endodermal origin of calcitonin-producing neuroendocrine cells.

Autor:	Rees JM; Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK., Kirk K; Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK., Gattoni G; Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.; Department of Biological Sciences, Columbia University, New York City, NY 10027, USA., Hockman D; Division of Cell Biology, Department of Human Biology, University of Cape Town, Cape Town 7935, South Africa.; Neuroscience Institute, University of Cape Town, Cape Town 7935, South Africa., Sleight VA; Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK., Ritter DJ; Department of Cell and Developmental Biology, Vanderbilt School of Medicine, Nashville, TN 37240, USA., Benito-Gutierrez È; Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK., Knapik EW; Department of Cell and Developmental Biology, Vanderbilt School of Medicine, Nashville, TN 37240, USA.; Vanderbilt Genetics Institute, Vanderbilt School of Medicine, Nashville, TN 37232, USA., Crump JG; Eli and Edythe Broad Center for Regenerative Medicine, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Fabian P; Eli and Edythe Broad Center for Regenerative Medicine, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Gillis JA; Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.; Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA 02543, USA.
Jazyk:	angličtina
Zdroj:	Development (Cambridge, England) [Development] 2024 Oct 15; Vol. 151 (20). Date of Electronic Publication: 2024 Aug 07.
DOI:	10.1242/dev.202821
Abstrakt:	Vertebrate calcitonin-producing cells (C-cells) are neuroendocrine cells that secrete the small peptide hormone calcitonin in response to elevated blood calcium levels. Whereas mouse C-cells reside within the thyroid gland and derive from pharyngeal endoderm, avian C-cells are located within ultimobranchial glands and have been reported to derive from the neural crest. We use a comparative cell lineage tracing approach in a range of vertebrate model systems to resolve the ancestral embryonic origin of vertebrate C-cells. We find, contrary to previous studies, that chick C-cells derive from pharyngeal endoderm, with neural crest-derived cells instead contributing to connective tissue intimately associated with C-cells in the ultimobranchial gland. This endodermal origin of C-cells is conserved in a ray-finned bony fish (zebrafish) and a cartilaginous fish (the little skate, Leucoraja erinacea). Furthermore, we discover putative C-cell homologs within the endodermally-derived pharyngeal epithelium of the ascidian Ciona intestinalis and the amphioxus Branchiostoma lanceolatum, two invertebrate chordates that lack neural crest cells. Our findings point to a conserved endodermal origin of C-cells across vertebrates and to a pre-vertebrate origin of this cell type along the chordate stem. Competing Interests: Competing interests È.B.-G. has been employed by Genentech since September 2022. The rest of the authors declare no competing interests. (© 2024. Published by The Company of Biologists Ltd.)
Databáze:	MEDLINE
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