Weaning Outcome is Associated with ELWI and Impaired Diastolic Function.
| Autor: | Bagka D; General University Hospital of Larissa, Larisa, Greece., Zakynthynos G; University of Athens, Athens, Greece., Tsolaki V; General University Hospital of Larissa, Larisa, Greece., Papanikolaou J; General Hospital of Trikala, Greece., Vazgiourakis V; General University Hospital of Larissa, Larisa, Greece., Baka M; General University Hospital of Larissa, Larisa, Greece., Pratsas K; General University Hospital of Larissa, Larisa, Greece., Makris D; General University Hospital of Larissa, Larisa, Greece. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) [J Crit Care Med (Targu Mures)] 2024 Jan 30; Vol. 10 (1), pp. 64-72. Date of Electronic Publication: 2024 Jan 30 (Print Publication: 2024). |
| DOI: | 10.2478/jccm-2024-0008 |
| Abstrakt: | Objectives: To evaluate hemodynamic profiles of critical care patients undergoing spontaneous t-piece trial (SBT) and present weaning failure. Methods: Prospective observational study conducted in ready-to-wean non-cardiac ICU patients. Clinical, echocardiographic and thermodilution-derived variables were recorded before and after a 2-hour SBT. Weaning from mechanical ventilation was defined as preservation of spontaneous breathing for 48 hours following successful SBT. Results: Fourteen patients succeeded weaning, five manifested T-trial-failure and six late-failure. Weaning outcome was significantly associated with ELWI(Extravascular lung-water index), global-end-diastolic index and impaired diastolic function, as indicated by pre-T Doppler early wave velocities (E/Em); Fifty-six percent of participants presented ELWI≥7mL/kg when fulfilling predetermined criteria for weaning. ELWI, impaired pulmonary permeability and left ventricular diastolic dysfunction were independent determinants of ELWI. Conclusions: ELWI before SBT and impaired diastolic function (as indicated by pre-T E/Em) might be weaning outcome determinants and their assessment may allow better risk stratification in weaning decision making. Competing Interests: Conflict of interest None to declare. (© 2024 Dimitra Bagka et al., published by Sciendo.) |
| Databáze: | MEDLINE |
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