Crystal structure of Staudtienic acid, a diterpenoid from Staudtia kamerunensis Warb. (Myristicaceae).

Autor: Tonga Lembe J; Drug Discovery and Smart Molecules Research Laboratory, Department of Chemical, Sciences, University of Johannesburg, PO Box 17011, Doornfontein, Johannesburg 2028, South Africa.; Centre for Natural Product Research (CNPR), Department of Chemical Sciences, University of Johannesburg, Doornfontein, Johannesburg 2028, South Africa., Mphahlele PM; Drug Discovery and Smart Molecules Research Laboratory, Department of Chemical, Sciences, University of Johannesburg, PO Box 17011, Doornfontein, Johannesburg 2028, South Africa.; Centre for Natural Product Research (CNPR), Department of Chemical Sciences, University of Johannesburg, Doornfontein, Johannesburg 2028, South Africa., Kamdem Kengne MH; Drug Discovery and Smart Molecules Research Laboratory, Department of Chemical, Sciences, University of Johannesburg, PO Box 17011, Doornfontein, Johannesburg 2028, South Africa.; Centre for Natural Product Research (CNPR), Department of Chemical Sciences, University of Johannesburg, Doornfontein, Johannesburg 2028, South Africa., Jiyane P; Drug Discovery and Smart Molecules Research Laboratory, Department of Chemical, Sciences, University of Johannesburg, PO Box 17011, Doornfontein, Johannesburg 2028, South Africa.; Centre for Natural Product Research (CNPR), Department of Chemical Sciences, University of Johannesburg, Doornfontein, Johannesburg 2028, South Africa., Djuidje Fotsing MC; Drug Discovery and Smart Molecules Research Laboratory, Department of Chemical, Sciences, University of Johannesburg, PO Box 17011, Doornfontein, Johannesburg 2028, South Africa.; Centre for Natural Product Research (CNPR), Department of Chemical Sciences, University of Johannesburg, Doornfontein, Johannesburg 2028, South Africa., Ardene C; Centre for Natural Product Research (CNPR), Department of Chemical Sciences, University of Johannesburg, Doornfontein, Johannesburg 2028, South Africa.; Research Centre for Synthesis and Catalysis, Department of Chemical Sciences, University of Johannesburg-Kingsway Campus, Auckland Park 2008, South Africa., Mmutlane EM; Research Centre for Synthesis and Catalysis, Department of Chemical Sciences, University of Johannesburg-Kingsway Campus, Auckland Park 2008, South Africa.; Centre for Natural Product Research (CNPR), Department of Chemical Sciences, University of Johannesburg, Doornfontein, Johannesburg 2028, South Africa., Ndinteh DT; Drug Discovery and Smart Molecules Research Laboratory, Department of Chemical, Sciences, University of Johannesburg, PO Box 17011, Doornfontein, Johannesburg 2028, South Africa.; Centre for Natural Product Research (CNPR), Department of Chemical Sciences, University of Johannesburg, Doornfontein, Johannesburg 2028, South Africa.
Jazyk: angličtina
Zdroj: Acta crystallographica. Section E, Crystallographic communications [Acta Crystallogr E Crystallogr Commun] 2024 Jul 19; Vol. 80 (Pt 8), pp. 878-881. Date of Electronic Publication: 2024 Jul 19 (Print Publication: 2024).
DOI: 10.1107/S2056989024005000
Abstrakt: This title compound, C 20 H 26 O 2 , was isolated from the benzene fraction of the stem bark of Staudtia kamerunensis Warb. (Myristicaceae) using column chromatography techniques over silica gel. The compound was fully characterized by single-crystal X-ray diffraction, one and two-dimensional NMR spectroscopy, IR and MS spectrometry. The compound has two fused cyclo-hexane rings attached to a benzene ring, with a carb-oxy-lic acid on C-4. This cyclo-hexene ring has a chair conformation while the other adopts a half-chair conformation. The benzene ring is substituted with a propenyl moiety. The structure is characterized by inter-molecular O-H⋯O hydrogen bonds, two C-H⋯O intra-molecular hydrogen bonds and two C-H⋯π inter-actions. The mol-ecular structure confirms previous studies carried out by spectroscopic techniques.
(© Tonga Lembe et al. 2024.)
Databáze: MEDLINE
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