Management of patients with concurrent clonal plasma cell and myeloid disorders: A single center descriptive case series.

Autor:	Hochman MJ; Division of Hematological Malignancies and Bone Marrow Transplantation, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, United States.; Division of Hematology, Department of Medicine, Johns Hopkins University, Baltimore, MD, United States., Gerber GF; Division of Hematology, Department of Medicine, Johns Hopkins University, Baltimore, MD, United States., Imus PH; Division of Hematological Malignancies and Bone Marrow Transplantation, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, United States., Ali SA; Division of Hematological Malignancies and Bone Marrow Transplantation, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, United States., DeZern AE; Division of Hematological Malignancies and Bone Marrow Transplantation, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, United States.
Jazyk:	angličtina
Zdroj:	Leukemia research reports [Leuk Res Rep] 2024 Jul 09; Vol. 22, pp. 100469. Date of Electronic Publication: 2024 Jul 09 (Print Publication: 2024).
DOI:	10.1016/j.lrr.2024.100469
Abstrakt:	Both clonal plasma cell and myeloid disorders occur more frequently with age. Patients with concurrent clonal plasma cell and myeloid disorders (CPCMD) can present clinical and therapeutic challenges. In this single-institution cohort of patients with CPCMD ( n = 18), we abstracted clinically relevant themes. A majority of patients (12/18) were treated with clone-directed therapies and three received treatment targeting both clones. Treatment of clones with targetable genetic lesions or those causing end-organ complications should be prioritized. Simultaneous treatment of both clones can be safe but is best done in a stepwise manner. Further study of patients with dual clonal processes is warranted. Competing Interests: None (© 2024 The Authors. Published by Elsevier Ltd.)
Databáze:	MEDLINE
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