Epithelial-mesenchymal transition in chemoradiation-induced lung damage: Mechanisms and potential treatment approaches.

Autor: Saadh MJ; Faculty of Pharmacy, Middle East University, Amman, Jordan., Sharma P; Department of Chemistry, School of Sciences, Jain (Deemed-to-be) University, Bengaluru, India.; Department of Sciences, Vivekananda Global University, Jaipur, India., Naser IH; Medical Laboratories Techniques Department, AL-Mustaqbal University, Hillah, Iraq., Kumar A; School of Pharmacy-Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, India.; Department of Pharmacy, Arka Jain University, Jamshedpur, India., Ravi Kumar M; Department of Chemistry, Raghu Engineering College, Visakhapatnam, Andhra Pradesh, India., Rasulova I; Central Asian Center of Development Studies, New Uzbekistan University, Tashkent, Uzbekistan.; Department of Public Health, Samarkand State Medical University, Samarkand, Uzbekistan., Mohammed F; Department of Medical Laboratories technology, Al-Manara College for Medical Sciences, (Maysan), Iraq., Allela OQB; Department of Pharmacy, Al-Noor University College, Nineveh, Iraq., Mohammed WK; Department of Medical Laboratories Technology, Al-Hadi University College, Baghdad, Iraq., Ahmed NM; College of Pharmacy, National University of Science and Technology, Nasiriyah, Iraq., Al-Ani AM; Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq., Redhee AH; Medical Laboratory Technique College, The Islamic University, Najaf, Iraq.; Medical Laboratory Technique College, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.; Medical Laboratory Technique College, The Islamic University of Babylon, Babylon, Iraq.
Jazyk: angličtina
Zdroj: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2024 Aug; Vol. 38 (8), pp. e23790.
DOI: 10.1002/jbt.23790
Abstrakt: Pulmonary injury is one of the key restricting factors for the therapy of malignancies with chemotherapy or following radiotherapy for chest cancers. The lung is a sensitive organ to some severely toxic antitumor drugs, consisting of bleomycin and alkylating agents. Furthermore, treatment with radiotherapy may drive acute and late adverse impacts on the lung. The major consequences of radiotherapy and chemotherapy in the lung are pneumonitis and fibrosis. Pneumonitis may arise some months to a few years behind cancer therapy. However, fibrosis is a long-term effect that appears years after chemo/or radiotherapy. Several mechanisms such as oxidative stress and severe immune reactions are implicated in the progression of pulmonary fibrosis. Epithelial-mesenchymal transition (EMT) is offered as a pivotal mechanism for lung fibrosis behind chemotherapy and radiotherapy. It seems that pulmonary fibrosis is the main consequence of EMT after chemo/radiotherapy. Several biological processes, consisting of the liberation of pro-inflammatory and pro-fibrosis molecules, oxidative stress, upregulation of nuclear factor of κB and Akt, epigenetic changes, and some others, may participate in EMT and pulmonary fibrosis behind cancer therapy. In this review, we aim to discuss how chemotherapy or radiotherapy may promote EMT and lung fibrosis. Furthermore, we review potential targets and effective agents to suppress EMT and lung fibrosis after cancer therapy.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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