One-year changes in body composition and musculoskeletal health following metabolic/bariatric surgery.

Autor:	Jassil FC; Centre for Obesity Research, University College London, London, UK.; Bariatric Centre for Weight Management and Metabolic Surgery, University College London Hospitals NHS Trust, London, UK.; National Institute for Health Research, UCLH Biomedical Research Centre, London, UK., Papageorgiou M; Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Diabetes Centre, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Mackay E; Centre for Obesity Research, University College London, London, UK., Carnemolla A; Centre for Obesity Research, University College London, London, UK.; Bariatric Centre for Weight Management and Metabolic Surgery, University College London Hospitals NHS Trust, London, UK.; National Institute for Health Research, UCLH Biomedical Research Centre, London, UK., Kingett H; Centre for Obesity Research, University College London, London, UK.; Bariatric Centre for Weight Management and Metabolic Surgery, University College London Hospitals NHS Trust, London, UK., Doyle J; Centre for Obesity Research, University College London, London, UK.; Bariatric Centre for Weight Management and Metabolic Surgery, University College London Hospitals NHS Trust, London, UK., Kirk A; Centre for Obesity Research, University College London, London, UK.; Bariatric Centre for Weight Management and Metabolic Surgery, University College London Hospitals NHS Trust, London, UK., Lewis N; The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, University College London, London, UK., Montagut G; Centre for Obesity Research, University College London, London, UK.; Bariatric Centre for Weight Management and Metabolic Surgery, University College London Hospitals NHS Trust, London, UK.; National Institute for Health Research, UCLH Biomedical Research Centre, London, UK., Marvasti P; Centre for Obesity Research, University College London, London, UK., Brown A; Centre for Obesity Research, University College London, London, UK.; Bariatric Centre for Weight Management and Metabolic Surgery, University College London Hospitals NHS Trust, London, UK.; National Institute for Health Research, UCLH Biomedical Research Centre, London, UK., Chaiyasoot K; Centre for Obesity Research, University College London, London, UK.; Bariatric Centre for Weight Management and Metabolic Surgery, University College London Hospitals NHS Trust, London, UK.; National Institute for Health Research, UCLH Biomedical Research Centre, London, UK.; Division of Nutrition, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Zakeri R; Centre for Obesity Research, University College London, London, UK.; Bariatric Centre for Weight Management and Metabolic Surgery, University College London Hospitals NHS Trust, London, UK.; National Institute for Health Research, UCLH Biomedical Research Centre, London, UK., Mok J; Centre for Obesity Research, University College London, London, UK.; Bariatric Centre for Weight Management and Metabolic Surgery, University College London Hospitals NHS Trust, London, UK.; National Institute for Health Research, UCLH Biomedical Research Centre, London, UK.; Bariatric Surgery Department, Homerton University Hospital NHS Trust, London, UK., Wingrove J; NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London  UK., Collet TH; Diabetes Centre, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Service of Endocrinology, Diabetes, Nutrition and Therapeutic Education, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland., Devalia K; Bariatric Surgery Department, Homerton University Hospital NHS Trust, London, UK., Parmar C; Department of Surgery, Whittington Health NHS Trust, London, UK.; University College London, London, UK., Makaronidis J; Centre for Obesity Research, University College London, London, UK.; Bariatric Centre for Weight Management and Metabolic Surgery, University College London Hospitals NHS Trust, London, UK.; National Institute for Health Research, UCLH Biomedical Research Centre, London, UK., Batterham RL; Centre for Obesity Research, University College London, London, UK.; Bariatric Centre for Weight Management and Metabolic Surgery, University College London Hospitals NHS Trust, London, UK.; National Institute for Health Research, UCLH Biomedical Research Centre, London, UK.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Jul 23. Date of Electronic Publication: 2024 Jul 23.
DOI:	10.1210/clinem/dgae496
Abstrakt:	Context: There are limited comparative studies between one anastomosis gastric bypass (OAGB) versus Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on body composition and musculoskeletal health. Objective: To compare changes in body composition, areal bone mineral density (aBMD), muscle strength, and physical function in the first year following OAGB, RYGB and SG within a UK-based healthcare setting. Methods: This is a secondary analysis of the BARI-LIFESTYLE trial in 119 adults (77% women; mean±SD, age: 45.9±10.3 years; BMI: 43.6±5.5 kg/m2) who underwent OAGB (n=19), RYGB (n=39) and SG (n=61). Body composition and aBMD by dual energy x-ray absorptiometry, handgrip strength, sit-to-stand (STS) test and 6-minute walking test (6MWT) were assessed pre-surgery and at 12 months post-surgery. Results: OAGB, RYGB, and SG exhibited similar reductions in body weight, body fat and lean mass (within-group comparisons, p<0.001). All surgery types were associated with reductions in aBMD at the total hip, femoral neck, and lumbar spine, which were more pronounced after OAGB and RYGB compared to SG (all p<0.03), though no difference between OAGB and RYGB. Despite reductions in absolute handgrip strength, relative handgrip strength, STS test and 6MWT improved post-surgery (all p<0.02), with no differences by surgical procedure. Conclusion: OAGB, RYGB, and SG resulted in comparable weight loss, changes in body composition and improvements in relative muscle strength and physical function. OAGB and RYGB, compared with SG, led to greater BMD reductions at clinically relevant sites. Future long-term studies should explore whether these BMD reductions translate into a greater fracture risk. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu