| Autor: |
Tuksar M; Teva's Global R&D, Small Molecules CoE, Chemical R&D, Prilaz baruna Filipovića 25, Zagreb 10000, Croatia., Topić E; Faculty of Science, University of Zagreb, Horvatovac 102a, Zagreb 10000, Croatia., Rubčić M; Faculty of Science, University of Zagreb, Horvatovac 102a, Zagreb 10000, Croatia., Meštrović E; Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Marulića 19, Zagreb 10000, Croatia. |
| Jazyk: |
angličtina |
| Zdroj: |
Molecular pharmaceutics [Mol Pharm] 2024 Sep 02; Vol. 21 (9), pp. 4700-4707. Date of Electronic Publication: 2024 Aug 06. |
| DOI: |
10.1021/acs.molpharmaceut.4c00670 |
| Abstrakt: |
This study examines pharmaceutically acceptable inorganic salts of memantine, specifically focusing on hydrogen sulfate, sulfate, and dihydrogen phosphate salts, with the aim of finding alternatives to the commonly used chloride salt in the treatment of Alzheimer's disease. Through comprehensive solid-state characterization, including powder X-ray diffraction, thermal analysis, and solubility testing, we unveil complex polymorphic behaviors, reversible solid-state transitions, and significant differences in solubility and stability among the salts. Notably, the hydrogen sulfate salt emerges as a promising candidate for drug formulations, offering improved solubility, nonhygroscopic nature, and favorable morphological characteristics compared to the existing chloride salt. This work establishes a foundation for further investigation into memantine salts as potential therapeutics with improved efficacy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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