Opioids and personalized analgesia in the perioperative setting: A protocol for five systematic reviews.

Autor:	Karlsen APH; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Sunde PB; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Olsen MH; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Roskilde, Denmark.; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Neuroanaesthesiology, Neuroscience Centre, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Laigaard J; Department of Orthopedic surgery, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Folkersen C; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Roskilde, Denmark., Tran TXM; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Rasmussen IH; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Roskilde, Denmark., Kjartansdóttir S; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Department of Clinical Pharmacology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Saito A; Pontifical Catholic University of Campinas, Sao Paulo, Brazil., Andersen MA; Department of Clinical Pharmacology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark., Maagaard M; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Roskilde, Denmark., Papadomanolakis-Pakis N; Department of Anaesthesia and Intensive Care, Aarhus University Hospital, Aarhus, Denmark., Dalhoff K; Department of Clinical Pharmacology, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Nikolajsen L; Department of Anaesthesia and Intensive Care, Aarhus University Hospital, Aarhus, Denmark., Lunn TH; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Department of Anaesthesia and Intensive Care, Aarhus University Hospital, Aarhus, Denmark., Meyhoff CS; Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Jakobsen JC; Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Mathiesen O; Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Roskilde, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Jazyk:	angličtina
Zdroj:	Acta anaesthesiologica Scandinavica [Acta Anaesthesiol Scand] 2024 Nov; Vol. 68 (10), pp. 1573-1580. Date of Electronic Publication: 2024 Aug 06.
DOI:	10.1111/aas.14508
Abstrakt:	Background: Treatment with opioids is a mainstay in perioperative pain management. While the leading treatment paradigm has been procedure-specific pain management, efforts regarding personalized pain treatment are increasing. The OPI•AID project aims to develop personalized algorithms for perioperative pain management, taking demographic, surgical, and anaesthesiologic factors into account. We will undertake five parallel reviews to illuminate current evidence on different aspects of individual responses to perioperative opioid treatment. Methods: Inclusion of adult populations in English-written studies. Review-specific searches are developed for the following databases: CENTRAL, MEDLINE, Embase, clinicaltrials.gov, and clinicaltrial.eu. Two authors will independently screen citations, extract data, and assess the risks of bias in each review (QUIPS, PROBAST and RoB2, as relevant). Conclusion: These reviews will evaluate various aspects of perioperative opioid treatment, including individualized treatment strategies, selection of specific opioids, and individual patient responses. These will guide future development of a personalized perioperative opioid treatment algorithm (OPI•AID) that will be validated and tested clinically against standard of care. (© 2024 The Author(s). Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.)
Databáze:	MEDLINE
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