Measurement of hepatic glucose ( 18 F-fluorodeoxyglucose) uptake with positron emission tomography-magnetic resonance imaging in fumonisin B intoxicated rabbit bucks.

Autor: Szabó A; Agribiotechnology and Precision Breeding for Food Security National Laboratory, Department of Physiology and Animal Health, Institute of Physiology and Nutrition, Hungarian University of Agriculture and Life Sciences, Kaposvár, Hungary. szabo.andras@uni-mate.hu.; HUN-REN-MATE Mycotoxins in the Food Chain Research Group, Kaposvár, Hungary. szabo.andras@uni-mate.hu., Emri M; Division of Nuclear Medicine and Translational Imaging, Department of Medical Imaging, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.; Medicopus Healthcare Provider and Public Nonprofit Ltd, Somogy County Moritz Kaposi Teaching Hospital, Kaposvár, Hungary., Tóth Z; Medicopus Healthcare Provider and Public Nonprofit Ltd, Somogy County Moritz Kaposi Teaching Hospital, Kaposvár, Hungary., Fajtai D; Medicopus Healthcare Provider and Public Nonprofit Ltd, Somogy County Moritz Kaposi Teaching Hospital, Kaposvár, Hungary., Donkó T; Medicopus Healthcare Provider and Public Nonprofit Ltd, Somogy County Moritz Kaposi Teaching Hospital, Kaposvár, Hungary., Petneházy Ö; Agribiotechnology and Precision Breeding for Food Security National Laboratory, Department of Physiology and Animal Health, Institute of Physiology and Nutrition, Hungarian University of Agriculture and Life Sciences, Kaposvár, Hungary.; Medicopus Healthcare Provider and Public Nonprofit Ltd, Somogy County Moritz Kaposi Teaching Hospital, Kaposvár, Hungary., Kőrösi D; Medicopus Healthcare Provider and Public Nonprofit Ltd, Somogy County Moritz Kaposi Teaching Hospital, Kaposvár, Hungary., Repa I; Medicopus Healthcare Provider and Public Nonprofit Ltd, Somogy County Moritz Kaposi Teaching Hospital, Kaposvár, Hungary., Takács A; Medicopus Healthcare Provider and Public Nonprofit Ltd, Somogy County Moritz Kaposi Teaching Hospital, Kaposvár, Hungary., Kisiván T; Medicopus Healthcare Provider and Public Nonprofit Ltd, Somogy County Moritz Kaposi Teaching Hospital, Kaposvár, Hungary., Gerencsér Z; Department of Animal Breeding, Institute of Animal Sciences, Hungarian University of Agricultural and Life Sciences, Kaposvár, Hungary., Ali O; Agribiotechnology and Precision Breeding for Food Security National Laboratory, Department of Physiology and Animal Health, Institute of Physiology and Nutrition, Hungarian University of Agriculture and Life Sciences, Kaposvár, Hungary., Turbók J; Agribiotechnology and Precision Breeding for Food Security National Laboratory, Department of Physiology and Animal Health, Institute of Physiology and Nutrition, Hungarian University of Agriculture and Life Sciences, Kaposvár, Hungary.; National Food Chain Safety Office, Animal Health Directorate, Animal Health Diagnostic Laboratory, Kaposvár, Hungary., Bóta B; HUN-REN-MATE Mycotoxins in the Food Chain Research Group, Kaposvár, Hungary., Gömbös P; Agribiotechnology and Precision Breeding for Food Security National Laboratory, Department of Physiology and Animal Health, Institute of Physiology and Nutrition, Hungarian University of Agriculture and Life Sciences, Kaposvár, Hungary., Romvári R; Department of Animal Breeding, Institute of Animal Sciences, Hungarian University of Agricultural and Life Sciences, Kaposvár, Hungary., Kovács M; Agribiotechnology and Precision Breeding for Food Security National Laboratory, Department of Physiology and Animal Health, Institute of Physiology and Nutrition, Hungarian University of Agriculture and Life Sciences, Kaposvár, Hungary.; HUN-REN-MATE Mycotoxins in the Food Chain Research Group, Kaposvár, Hungary.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Aug 06; Vol. 14 (1), pp. 18213. Date of Electronic Publication: 2024 Aug 06.
DOI: 10.1038/s41598-024-68210-3
Abstrakt: Rabbit bucks (bodyweight 5 kg) underwent dietary intoxication with fumonisin B series mycotoxins (FB 1  + FB 2  + FB 3 , 15 mg/kg diet) for 14 days to test the applicability of positron emission tomography-magnetic resonance (PET MR) hybrid imaging in characterizing experimentally induced mild hepatotoxicosis. 18 F-fluorodeoxyglucose ( 18 F-FDG) radiotracer-aided imaging was performed before and after FBs administration on identical animals, and at both time points, blood was sampled for haematology and clinical chemistry. Kinetic PET image analysis revealed time-activity curves with uptake maxima below 1 min in the liver, renal cortex, portal vein, lung and coarctatio aortae. In the frame of static PET image analysis, based on the standardized uptake value (SUV), the so-called metabolic liver volume (MLV, liver volume defined by over 0.9 × average liver SUV) and the total liver glycolysis (TLG, MLV multiplied by the SUVmean) were calculated. Mycotoxicosis increased total liver glycolysis (p < 0.04) after 14 days and liver tissue TLG inhomogeneity was minimal. Pearson correlation between TLG and alkaline phosphatase (ALP) was positive (0.515), while negative with LDH and AST (- 0.721 and - 0.491, respectively). Results indicate a slight hepatic mycotoxin effect and significantly increased glucose uptake intensity, which has been sensitively detected with molecular imaging ( 18 F-FDG PET MRI) in the rabbit model.
(© 2024. The Author(s).)
Databáze: MEDLINE
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