Metabolism: Secretory autophagy balances nutrient supply and demand.
| Autor: | Leidal AM; Snyder Institute for Chronic Diseases and Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. Electronic address: andrew.leidal@ucalgary.ca. |
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| Jazyk: | angličtina |
| Zdroj: | Current biology : CB [Curr Biol] 2024 Aug 05; Vol. 34 (15), pp. R724-R726. |
| DOI: | 10.1016/j.cub.2024.06.044 |
| Abstrakt: | The hormone leptin is critical for regulation of food intake, energy expenditure and overall metabolism. However, the mechanisms that promote leptin secretion from adipocytes in response to nutrient surplus and limit its secretion during nutrient scarcity are unclear. New work reveals that the autophagy protein Atg8/LC3 has a bidirectional role in leptin secretion, both facilitating and limiting its release. Competing Interests: Declaration of interests The author declares no competing interests. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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